Figure 4.

Forest plot presentation of voclosporin drug–drug interaction studies. Point estimate and 90% confidence interval is shown for change in substrate exposure following co-administration of voclosporin with ketoconazole, rifampin and verapamil, where voclosporin is the substrate; and co-administration of voclosporin with midazolam and digoxin, where midazolam and digoxin are the substrates. Abbreviations are as follows: AUC, area under the concentration–time curve; CI, confidence interval; C_max, maximal whole blood or plasma concentration; PK, pharmacokinetics; TDM, therapeutic drug monitoring