Table 3.
Pharmacokinetic parameters for voclosporin after oral administration of voclosporin 0.4 mg kg−1 alone and after 10 days of rifampin 600 mg once daily
| Parameter | Voclosporin alone | Voclosporin + rifampin |
|---|---|---|
| (n = 24) | (n = 22) | |
| Tmax (h) | 1.75 | 1.0 |
| Cmax (ng ml−1) | 90.0 ± 39.6 | 27.3 ± 12.7 |
| GMR % (90% CI) | – | 31.8 (27.5–36.8) |
| AUC(0–t) (h ng ml−1) | 306 ± 151 | 37.1 ± 14.8 |
| GMR % (90% CI) | – | 13.2 (11.5–15.2) |
| AUC(inf) (h ng ml−1) | 331 ± 166 | 40.5 ± 17.4 |
| GMR % (90% CI) | – | 13.1 (11.4–15.1) |
| Λz (h−1) | 0.155 ± 0.072 | 0.998 ± 0.380 |
| t1/2 (h) | 4.96 ± 3.05 | 0.82 ± 0.45 |
Values are shown as means ± SD except Tmax, for which the median is reported. Abbreviations are as follows: AUC, area under the curve; CI, confidence interval; Cmax, maximal concentration; GMR, geometric least squares mean ratio (comparison to voclosporin alone) based on analysis of natural log-transformed data; Λz, elimination rate constant; Tmax, time to reach maximal concentration.