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. 2014 Apr 16;90(6):123. doi: 10.1095/biolreprod.114.117473

FIG. 2.

FIG. 2

Effects of LH, PDGF-AA, and PDGF-BB on SLC differentiation from stem cells. A) Testosterone in the media of isolated seminiferous tubules cultured with LH for 1 to 4 wk. B) Effects of PDGF-AA and PDGF-BB on testosterone formation. Seminiferous tubules were cultured for 4 wk with LH, LH plus PDGF-AA, or LH plus PDGF-BB. Asterisks indicate significant differences from testosterone formation in response to LH alone. C) Mechanism by which PDGF-BB inhibits testosterone formation. The testosterone concentrations resulting from the tubules cultured with LH, LH plus PDGF-BB, or LH plus PDGF-BB plus the PDGFRβ inhibitor 521233 were determined. aSignificantly different from LH-only control. bSignificantly different from LH plus PDGF-BB control. cSignificantly different from LH plus 521233. In B and C, testosterone levels are expressed as percentages relative to LH alone, which is set at 100%. Error bars are the mean (SEM).