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. Author manuscript; available in PMC: 2014 Jul 11.
Published in final edited form as: J Biochem Mol Toxicol. 2009 May-Jun;23(3):202–211. doi: 10.1002/jbt.20281

FIGURE 4.

FIGURE 4

BHA inhibits E2-induced 8-isoPGF2α formation. Female ACI rats were treated with cholesterol, E2, cholesterol + BHA, or E2 + BHA as described in Methods section. 8-isoPGF2α levels were measured in mammary tissue from animals in each of these groups. 8-isoPGF2α levels were assessed in mammary tumor as well. Fold changes were calculated for E2-treated animals relative to age-matched cholesterol-treated controls. Fold changes were calculated for E2 + BHA-treated animals relative to age-matched BHA-treated controls. Fold change data for tumor tissue were determined by comparing 8-isoPGF2α levels in tumor tissue to levels detected in nontumor mammary tissue from age-matched control rats. These data are reported as an average of values obtained for at least eight different animals ± SEM. *indicates a p value < 0.05 relative to each group’s respective controls. †indicates a p value < 0.05 when comparing E2 and E2 + BHA groups.