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The compound was prepared as a racemic mixture of a single diastereomer. (a) PIFA (1.2 equiv), NaHCO3 (4 equiv), MeCN, H2O, 0°C, 1 h, 69%. (b) NaHCO3 (5 equiv), MeOH, rt, 15 h, 92%. (c) POCl3 (2.5 equiv), pyridine, rt, 15 h, 86%. (d) NaBH4 (1.0 equiv), CeCl3 (0.1 equiv), MeOH, −30 °C, 30 min, 90%; NaH (1.5 equiv), DMF, 0 °C, 30 min, then MeI (5 equiv), rt, 15 h, 86%; LAH (3 equiv), THF, 70 °C, 3 h, 89%.
