. 2014 May 20;5(7):766–770. doi: 10.1021/ml500094c

Table 1. Pharmacological Data of Fragments 1a, 2a, and 3a^a.

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		1a	2a	3a
K_i (μM)	α4β2	∼300	3.4 (5.46 ± 0.07)	∼30
	α4β4	>300	∼100	>300
	α3β4	>300	∼300	>300
IC₅₀ (μM)	α4β2	>300	∼30	∼100
IC₅₀ (μM)	α3β4	>300	>300	>300

The K_i values obtained for the compounds in the [³H]epibatidine binding assays are given in μM (with pK_i ± S.E.M. value in the bracket). The IC₅₀ values obtained for the compounds at α4β2 and α3β4 in the FMP assay are given in μM. The data are the means of 3–4 individual experiments.

Table 1. Pharmacological Data of Fragments 1a, 2a, and 3aa.

Table 1. Pharmacological Data of Fragments 1a, 2a, and 3a^a.