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. 2014 May 28;5(7):797–802. doi: 10.1021/ml500141f

Scheme 3. Synthesis of Oridonin Nitrogen Mustard Derivatives 16a–f, 17a–c, and 18a–c.

Scheme 3

Reagents and conditions: (a) 7, 8, 10, 11, 15, chlorambucil, EDCI, DMAP, DCM, rt, 12–24 h, 60%–82%; (b) 10, 15, chlorambucil, EDCI, DMAP, DCM, rt, 9–16 h, 71%–83%; (c) 10, 15, chlorambucil, EDCI, DMAP, DCM, rt, 12–18 h, 72–78%.