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. 2014 May 13;5(7):771–776. doi: 10.1021/ml500114p

Scheme 1. Synthesis of SM253 (Compound 7).

Scheme 1

Abbreviations: 1-hydroxybenzotriazole (HOBt), 1-hydroxy-7-azabenzotriazole (HOAt), dimethylformamide (DMF), N,N′-diisopropylcarbodiimide (DIC), 2,2,2-trifluoroethanol (TFE), 2-(1H-7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HATU), O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (TBTU), 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium chloride (DMTMM), N,N-diisopropylethylamine (DIPEA); sphere indicates CTC resin.