Table 3.
Mean peak (± SEM) subjective measures as a function of BUP dose and route of administration.
| IV | IN | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 0 mg | 2 mg | 4 mg | 8 mg | 16 mg | 0 mg | 2 mg | 4 mg | 8 mg | 16 mg | |
| Dependent Measure | ||||||||||
| SOWS Sum (0–64) | ||||||||||
| Sample Session Baseline | 7.4 (1.6) | 8.8 (2.2) | 6.4 (0.8) | 6.4 (1.5) | 5.7 (1.1) | 4.6 (0.6) | 4.5 (0.8) | 4.8 (0.7) | 5.2 (2.0) | 2.7 (0.6) |
| Choice Session Baseline | 3.74 (.89) | 3.60 (.90) | 3.57 (.84) | 3.76 (.67) | 4.74 (2.2) | 3.59 (.88) | 3.92 (1.71) | 3.29 (.91) | 4.15 (1.78) | 2.1 (.74) |
| VAS (0– 100) | ||||||||||
| Anxious | 6.4 (3.3) | 10.5 (4.9) | 12.2 (7.0) | 6.4 (3.4) | 2.3 (1.5) | 22.2# (2.3) | 15.8 (1.5) | 19.4 (1.5) | 23.2# (6.0) | 17.2# (3.4) |
| Bad | .21 (.21) | 2.1 (1.2) | 1.57 (1.4) | .14 (.14) | 3.6 (3.4) | 2.7# (2.7) | .38 (.38) | 1.9 (1.3) | 5.8 (5.7) | 6.0 (3.9) |
| Energetic | 24.1 (7.80 | 41.0 (7.3) | 37.0 (8.7) | 35.1 (8.1) | 31.3 (8.2) | 29.5 (9.1) | 33.8 (8.0) | 40.1 (10.1) | 35.8 (9.7) | 33.9 (9.6) |
| Gooseflesh | .43 (.36) | 2.4 (1.4) | 1.4 (1.2) | .28 (.28) | .14 (.14) | 2.2 (1.5) | 1.6 (1.3) | 4.5 (3.7) | 7.5 (6.1) | 0.0 (0.0) |
| High Quality | 5.6 (3.5) | 27.5 (8.2) | 37.3 (8.8) | 30.4 (9.0) | 35.6 (6.9) | 11.7 (6.1) | 11.2 (5.7) | 15.2 (6.9) | 16.5 (7.1) | 25.2 (9.1) |
| Irritable | 11.0 (6.6) | 5.3 (3.4) | 3.5 (1.7) | 13.8 (7.6) | 16.0 8.2) | 9.9 (3.8) | 8.5 (4.2) | 10.0 (6.5) | 9.1 (5.0) | 7.4 (4.3) |
| Liked the Dose | 1.6 (1.4) | 38.0 (9.5) | 40.8 (9.1) | 34.2 (9.3) | 43.9 (7.6) | 16.3# (6.9) | 11.5# (5.8) | 15.1# (6.3) | 17.5# (6.7) | 28.2# (9.8) |
| Mellow | 25.1 (5.8) | 49.3 (7.0) | 35.5 (8.3) | 31.6 (6.2) | 44.3 (6.2) | 36.5 (8.2) | 32.5 (9.4) | 36.9 (9.4) | 30.1 (8.4) | 40.5 (10.4) |
| Nauseated | 0.6 (0.5) | 5.4 (4.5) | 6.1 (5.8) | 4.1 (3.7) | 1.2 (0.8) | 3.6 (3.5) | 0.5 (0.5) | 0.8 (0.5) | 0.0 (0.0) | 3.9 (3.8) |
| Potent | 1.7 (1.3) | 25.4 (8.3) | 34.3 (8.6) | 29.4 (8.8) | 38.0 (8.6) | 9.7# (5.2) | 10.6# (5.6) | 17.1# (6.6) | 15.4# (7.3) | 25.3 (9.1) |
| Sedated | 1.9 (1.7) | 19.1 (5.8) | 26.9 (8.3) | 16.0 (6.9) | 30.4 (8.9) | 10.2# (5.6) | 7.6 (4.1) | 7.3# (4.0) | 15.6 (6.8) | 22.0 (8.8) |
| Sleepy | 24.1 (8.4) | 21.0 (7.1) | 13.2 (5.8) | 15.8 (5.5) | 16.5 (7.4) | 10.7 (5.8) | 16.4 (6.5) | 21.0 (8.3) | 18.9 (7.5) | 23.9 (8.1) |
| Social | 29.8 (6.3) | 50.5 (9.1) | 41.4 (7.0) | 38.2 (7.3) | 37.9 (7.1) | 32.7 (8.5) | 41.3 (8.6) | 43.8 (9.8) | 30.1 (8.8) | 35.5 (8.3) |
| Stimulated | 9.9 (5.6) | 29.0 (9.6) | 31.8 (9.6) | 23.5 (8.5) | 25.7 (9.1) | 13.8 (7.9) | 19.4 (8.7) | 25.2 (9.9) | 19.3 (6.7) | 24.1 (8.5) |
| Talkative | 29.6 (7.4) | 40.6 (8.7) | 41.6 (6.9) | 35.8 (7.9) | 32.3 (8.3) | 29.0 (8.5) | 32.6 (10.5) | 38.2 (10.4) | 25.0 (8.6) | 33.9 (9.7) |
| Would Pay | 0.0 (0.0) | 5.6 (1.6) | 8.2 (1.5) | 6.1 (1.5) | 8.8 (1.6) | 1.0 (0.5) | 1.4# (0.6) | 1.3# (0.7) | 4.1 (1.5) | 6.5 (2.2) |
| DEQ (0–4) | ||||||||||
| Bad | 0.1 (0.1) | 0.1 (0.2) | 0.2 (0.2) | 0.1 (0.1) | 0.9 (0.7) | 0.2 (0.1) | 0.1 (0.1) | 0.0 (0.0) | 0.1 (0.1) | 0.3 (0.2) |
| Good | 0.2 (0.4) | 1.5 (0.3) | 2.0 (0.3) | 1.6 (0.3) | 2.4 (0.6) | 0.5 (0.2) | 0.6 (0.2) | 1.0 (0.3) | 1.1 (0.3) | 1.5 (0.4) |
| Like | −0.4 (0.4) | 1.4 (0.5) | 2.4 (0.3) | 1.8 (0.3) | 2.4 (0.6) | −0.5 (0.4) | 0.2 (0.5) | 0.5# (0.5) | 0.6# (0.5) | 0.9# (0.6) |
| Strong | 0.4 (0.2) | 1.4 (0.3) | 2.1 (0.3) | 1.7 (0.3) | 2.5 (0.6) | 0.8 (0.2) | 0.9 (0.3) | 1.2 (0.3) | 1.0 (0.2) | 1.5 (0.3) |
| Take Again | 0.1 (0.4) | 1.6 (0.4) | 2.3 (0.3) | 1.8 (0.3) | 2.6 (0.6) | 0.7 (0.2) | 0.5# (0.2) | 0.9# (0.3) | 1.1 (0.4) | 1.2# (0.3) |
Bolded numbers indicates a significant difference from 0 mg, and
#
indicates a significant difference between IN and IV dosing.