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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Ageing Res Rev. 2014 Feb 2;14:31–42. doi: 10.1016/j.arr.2014.01.003

Figure 3.

Figure 3

The NMJ of old rats (2 years) shows profound changes in structure compared to young rats (56 days), and these can be ameliorated by exercise (2 months). Note the increase in NMJ size as indicated by the markers for the nerve terminal (NF+SV2=neurofilament+synaptic vesicle protein SV2) and the acetylcholine receptors (AChR) of the postsynaptic membrane. The severe loss of the presynaptic active zone protein, Bassoon, with ageing is rescued with exercise. Scale bar is 10 micrometers. This is reprinted from figure 3A in Nishimune et al. (2012); see this paper for more details.