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. 2014 Jul 11;9(7):e101764. doi: 10.1371/journal.pone.0101764

Figure 3. Combining focal radiation therapy with anti-4-1BB and anti-CTLA-4 antibodies results in long-term survival.

Figure 3

A) Schematic of the treatment protocol for triple therapy. B) Kaplan Meier survival curves for double immunotherapy and triple therapy (n = 18/group). Treatment with triple therapy was superior to double immunotherapy with anti-4-1BB and anti-CTLA-4 antibodies (p<0.05), focal RT alone (p<0.01) and untreated mice (p<0.001). Furthermore, triple therapy results in long-term survival in at least 50% of treated animals, whereas immunotherapy with both 4-1BB activation and CTLA-4 blockade produced long-term survival in 3/18 mice (16.7%). Data from three repeated experiments with similar results was pooled into single Kaplan Meier curves. P values were calculated with the Log-Rank test.