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. 2014 Jul 11;9(7):e101974. doi: 10.1371/journal.pone.0101974

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© 2014 Wang et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Pak1 regulates the activities of ion channels, Ca²⁺ handling and myofilament proteins through PP2A. Cardiac hypertrophy induced under pathological conditions is suppressed by Pak1 through JNK signaling and regulation of Cx43 expression and distribution.