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The binding of PLCγ1 to EGFR. (a) Two states “bndPLCg992” and “bndPLCg1173”, represented as red and blue squares, have to be “off” for PLC γ1 to be able to bind to site pY992. (b) All three states “bndPLCg992”, “bndPLCg1173” and “bndSHC1148”, represented as red, blue and green squares, have to be “off” for PLC γ1 to be able to bind to site pY1173.
