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. 2014 Jul 11;9(7):e101226. doi: 10.1371/journal.pone.0101226

Figure 1. Inoculations with Ad5-PPRV-F or Ad5-PPRV-H induce the production of PPRV-specific IgG in sheep.

Figure 1

Groups (n = 4) of sheep were inoculated intramuscularly with PBS, control adenovirus (Ad5), Ad-PPRV-F or Ad-PPRV-H at days 1 and 22 and all animals were challenged with virulent PPRV IVC 89 at day 42 (indicated by arrow). Serum samples obtained at the indicated time points were analysed for PPRV-specific IgG by ELISA using Nigeria 75/1 PPRV coated plates. Data are presented as average (+/−SEM) IgG titre for each treatment group. * p<0.01 in Wilcoxon matched-pairs signed rank test; day 7 vs day 0 in immunized sheep.** p<0.01 in Wilcoxon matched-pairs signed rank test; day 7 post-challenge vs day 42 pre-challenge. *** p<0.001 Mann-Whitney test: vaccinated (Ad5-PPRV-F and Ad5-PPRV-H) vs control (PBS and Ad5) sheep at the same time point.