Table 2.

SYNERGY data collection schedule

		Run-in Week −2	Intervention A & B
			Baseline	Mid point	End point
			Week 0 & 11	Week 3 & 14	Week 6 & 17
Serum uremic toxins	Indoxyl sulphate (free and total)	X	X	X	X
	P-cresyl sulphate (free and total)	X	X	X	X
Cardiovascular risk	Oxidative stress		X		X
	Inflammation		X		X
	Endotoxemia (lipopolysaccharide)		X		X
Kidney damage	24 hr albuminuria and protienuria		X		X
	Kidney injury molecule-1		X		X
	Estimated glomerular filtration rate	X	X		X
Dietary	Diet history interview	X			X
	24 hr recall		X	X
	24 hr urinary urea nitrogen		X		X
Quality of life	Short Form-36				X
Gastrointestinal symptoms	Gastrointestinal symptom rating scale	X		X	X
Gut microbiota	Fecal sample (optional)		X		X
Compliance	Pill count			X	X
Dose escalation				X