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. 2014 Jul 11;9(7):e102625. doi: 10.1371/journal.pone.0102625

Figure 2. Reverse-engineering a gene regulatory network for ZFP36 family identifies BCL2 mRNA as a direct target for ZFP36L1.

Figure 2

(A) Network graph image of inferred target mRNAs for ZFP36 family members. Edges represent regulatory interactions inferred from significant pair-wise statistical dependences calculated from MIC scores (see Table S2). A force-directed Cytoscape layout is shown. Identification of BCL2 mRNA as a direct target for ZFP36L1. (B) Candidate anti-apoptotic targets for ZFP36 family members identified from a reconstructed regulatory network. A hierarchical Cytoscape layout is shown.