. 2014 Jul 5;8:765–774. doi: 10.2147/DDDT.S63581

Table 1.

In vitro antibacterial activities of nemonoxacin and comparators against bacteria

Organism (# of isolates)	Quinolones	MIC (mg/L)
Organism (# of isolates)	Quinolones	Range	MIC₉₀
S. pneumoniae (655)	Nemonoxacin	≤0.008–0.25	0.015
	Ciprofloxacin	0.06–16	2
	Levofloxacin	0.06–32	1
	Moxifloxacin	0.06–8	0.25
Levofloxacin-susceptible	Nemonoxacin	0.06–0.25	0.12
S. pneumoniae (71)	Ciprofloxacin	1–16	4
	Levofloxacin	0.5–2	2
	Moxifloxacin	0.06–0.5	0.25
Levofloxacin-resistant	Nemonoxacin	0.5–8	2
S. pneumoniae (29)	Ciprofloxacin	8 to >16	>16
	Levofloxacin	8 to >16	>16
	Moxifloxacin	2 to >8	8
Penicillin-resistant	Nemonoxacin	0.015–0.06	0.03
S. pneumoniae (32)	Ciprofloxacin	0.5–8	2
	Levofloxacin	0.25–2	1
	Moxifloxacin	0.06–0.25	0.25
Levofloxacin-nonsusceptible	Nemonoxacin	0.12–4	1
S. pneumoniae (30)
Invasive S. pneumoniae (150)	Nemonoxacin	≤0.03–1	0.06
S. pyogenes (30)	Nemonoxacin	0.06–0.12	0.12
	Ciprofloxacin	0.25–4	4
	Levofloxacin	0.25–2	2
	Moxifloxacin	0.06–0.5	0.5
S. agalactiae (30)	Nemonoxacin	0.12–2	0.25
	Ciprofloxacin	1 to >16	2
	Levofloxacin	0.5 to >16	2
	Moxifloxacin	0.12 to >8	0.5
S. viridans (30)	Nemonoxacin	0.06–0.25	0.25
	Ciprofloxacin	0.25–4	4
	Levofloxacin	0.25–2	2
	Moxifloxacin	0.06–0.25	0.25
H. influenzae (30)	Nemonoxacin	≤0.008–8	4
	Ciprofloxacin	≤0.06–16	16
	Levofloxacin	≤0.06–8	8
	Moxifloxacin	≤0.015 to >8	>8
C. pneumoniae (10)	Nemonoxacin	0.03–0.125	0.06
	Levofloxacin	0.5	0.5
	Doxycycline	0.06–0.125	0.125
	Azithromycin	0.03–0.06	0.06
C. trachomatis (10)	Nemonoxacin	0.03–0.125	0.06
	Levofloxacin	0.125–0.5	0.25
	Doxycycline	0.03–0.25	0.125
	Azithromycin	0.003–0.03	0.015
Methicillin-susceptible	Nemonoxacin	≤0.03–0.06	≤0.03
S. aureus (100)
Methicillin-susceptible	Nemonoxacin	0.015–1	0.12
S. aureus (59)
Methicillin-susceptible	Nemonoxacin	≤0.008–32	0.12
S. aureus (374)	Ciprofloxacin	0.06–16	4
	Levofloxacin	0.06–32	1
	Moxifloxacin	0.06–16	0.25
Methicillin-resistant	Nemonoxacin	0.015–64	16
S. aureus (MRSA) (127)	Ciprofloxacin	0.25–16	16
	Levofloxacin	0.12–32	32
	Moxifloxacin	0.06–16	16
Ciprofloxacin-susceptible MRSA (50)	Nemonoxacin	≤0.03–0.06	≤0.03
Ciprofloxacin-susceptible MRSA (44)	Nemonoxacin	≤0.008–0.06	0.06
	Ciprofloxacin	≤0.06–1	0.5
	Levofloxacin	≤0.06–0.25	0.25
	Moxifloxacin	≤0.015–0.12	0.06
Ciprofloxacin-resistant MRSA (100)	Nemonoxacin	0.5–1	1
Ciprofloxacin-resistant MRSA (47)	Nemonoxacin	0.06–4	1
	Ciprofloxacin	2 to >16	>16
	Levofloxacin	0.5 to >16	16
	Moxifloxacin	0.12–8	4
Vancomycin-intermediate MRSA (50)	Nemonoxacin	0.03–8	2
Daptomycin-nonsusceptible MRSA (5)	Nemonoxacin	0.5–8
Levofloxacin-susceptible MRSA (355)	Nemonoxacin	≤0.008–0.12	0.06
	Ciprofloxacin	0.06–4	1
	Moxifloxacin	0.06–0.25	0.12
Levofloxacin-nonsusceptible MRSA (147)	Nemonoxacin	0.25–64	16
	Ciprofloxacin	16	16
	Moxifloxacin	1–16	16
Community-acquired MRSA (101)	Nemonoxacin	≤0.03–1	0.06
Community-acquired MRSA (25)	Nemonoxacin	0.015–2	0.5
	Ciprofloxacin	0.25–16	16
	Levofloxacin	0.12–16	8
	Moxifloxacin	0.06–4	2
Hospital-acquired MRSA (99)	Nemonoxacin	0.015–64	16
	Ciprofloxacin	0.5–16	16
	Levofloxacin	0.25–32	32
	Moxifloxacin	0.06–16	16
Coagulase-negative	Nemonoxacin	0.03–8	0.5
Staphylococcus, methicillin-resistant (68)	Ciprofloxacin	0.12 to >16	>16
	Levofloxacin	0.12 to >16	8
	Moxifloxacin	0.03 to >8	2
Methicillin-susceptible	Nemonoxacin	0.015–4	0.5
S. epidermidis (43)	Ciprofloxacin	0.06–16	16
	Levofloxacin	0.12–32	32
	Moxifloxacin	0.06–16	4
Methicillin-resistant	Nemonoxacin	0.012–2	2
S. epidermidis (9)	Ciprofloxacin	8–16	16
	Levofloxacin	4–32	32
	Moxifloxacin	1–16	16
E. faecalis (31)	Nemonoxacin	0.12–4	4
E. faecalis (81)	Nemonoxacin	0.03–128	1
	Ciprofloxacin	0.25–16	16
	Levofloxacin	0.25–32	32
	Moxifloxacin	0.06–16	16
E. faecium (19)	Nemonoxacin	0.5–8	8
E. faecium (38)	Nemonoxacin	0.06–128	128
	Ciprofloxacin	1–16	16
	Levofloxacin	1–32	32
	Moxifloxacin	0.25–16	16
Vancomycin-susceptible	Nemonoxacin	0.12–32	0.5
E. faecalis (50)
Vancomycin-resistant	Nemonoxacin	0.12–8	4
E. faecalis (34)
Vancomycin-susceptible	Nemonoxacin	0.06–8	4
E. faecium (50)
Vancomycin-resistant	Nemonoxacin	0.06–16	16
E. faecium (78)
E. coli (599)	Nemonoxacin	≤0.015 to ≥512	32
	Ciprofloxacin	0.06–16	16
	Levofloxacin	0.06–32	16
	Moxifloxacin	0.06–16	16
Ciprofloxacin-susceptible	Nemonoxacin	0.015–4	2
E. coli (37)	Ciprofloxacin	≤0.06–1	1
	Levofloxacin	≤0.06–2	1
	Moxifloxacin	≤0.015–2	1
Ciprofloxacin-resistant	Nemonoxacin	2 to >16	>16
E. coli (43)	Ciprofloxacin	2 to >16	>16
	Levofloxacin	1 to >16	>16
	Moxifloxacin	2 to >8	>8
K. pneumoniae (30)	Nemonoxacin	0.25 to >16	>16
K. pneumoniae (199)	Nemonoxacin	≤0.015–128	2
	Ciprofloxacin	0.06–16	0.5
	Levofloxacin	0.06–32	1
	Moxifloxacin	0.06–16	1
K. oxytoca (30)	Nemonoxacin	0.06–1	0.5
	Ciprofloxacin	0.06–0.25	0.06
	Levofloxacin	0.06–0.25	0.06
	Moxifloxacin	0.06–0.25	0.12
E. cloacae (30)	Nemonoxacin	0.5 to >16	>16
E. cloacae (72)	Nemonoxacin	0.06–32	0.5
	Ciprofloxacin	0.06–16	0.12
	Levofloxacin	0.06–32	0.25
	Moxifloxacin	0.06–16	0.25
P. mirabilis (30)	Nemonoxacin	0.5 to >16	>16
P. mirabilis (33)	Nemonoxacin	0.25 to ≥512	16
	Ciprofloxacin	0.06–2	2
	Levofloxacin	0.06–32	4
	Moxifloxacin	0.12–16	16
P. aeruginosa (30)	Nemonoxacin	1 to >16	>16
P. aeruginosa (137)	Nemonoxacin	≤0.015 to ≥512	32
	Ciprofloxacin	0.06–16	8
	Levofloxacin	0.06–32	16
	Moxifloxacin	0.06–16	16
A. baumannii (30)	Nemonoxacin	0.06 to >16	>16
A. baumannii (15)	Nemonoxacin	0.12–16	1
	Ciprofloxacin	0.12–32	4
	Levofloxacin	0.06–16	1
	Moxifloxacin	0.06–4	0.5
S. maltophilia (26)	Nemonoxacin	0.25–64	32
	Ciprofloxacin	0.06–16	16
	Levofloxacin	0.06–16	8
	Moxifloxacin	0.12–8	4
C. freundii (30)	Nemonoxacin	0.12 to >16	4
	Ciprofloxacin	≤0.06 to >16	2
	Levofloxacin	≤0.06 to >16	2
	Moxifloxacin	0.12 to >8	8

Note: Data from Adam HJ et al, Chen YH et al, Lauderdale TL et al, Chotikanatis K, Kohlhoff SA, Hammerschlag MR.4–7

Abbreviations: MIC, minimum inhibitory concentration; MRSA, methicillin-resistant Staphylococcus aureus.