Table S2.

Documented analgesics

Therapeutic class	International common denomination
Anticonvulsants
Carboxylic acid derivatives	Valproic acid
Gamma-aminobutyric acid analogs	Gabapentin, Pregabalin
Iminostilbene	Carbamazepine, Oxcarbazepine
Other anticonvulsants	Divalproex, Lamotrigine, Topiramate
Antidepressants
Selective serotonin reuptake inhibitors	Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Trazodone
Serotonin and noradrenaline reuptake inhibitors	Duloxetine, Venlafaxine
Tricyclic and tetracyclic antidepressants	Amitriptyline, Clomipramine, Desipramine, Doxepin, Imipramine, Maprotiline, Mirtazapine, Nortriptyline, Trimipramine
Other antidepressants	Bupropion
Antiretroviral	Acyclovir, Famciclovir, Valacyclovir
Disease-modifying antirheumatic drugs	Auranofin, Aurothioglucose, Aurothiomalate, Azathioprine, Chloroquine, Cyclosporine, D-penicillamine, Hydroxychloroquine, Leflunomide, Methotrexate, Sulfasalazine
Muscle relaxants
Benzodiazepine	Diazepam, Tetrazepam
Carbamic acid derivatives	Methocarbamol
Centrally acting myorelaxants	Cyclobenzaprine, Tizanidine
Gamma-aminobutyric acid derivatives	Baclofen
Other muscle relaxants	Thiocolchicoside
Nonsteroidal antiinflammatory
Acetic acids	Diclofenac, Etodolac, Indomethacin, Ketorolac, Nabumetone
Acetylsalicylic acid
Coxibs	Celecoxib
Fenamates	Meclofenamate, Mefenamic acid
Oxicams	Meloxicam, Piroxicam
Propionic acids	Fenoprofen, Flurbiprofen, Ibuprofen, Ketoprofen, Naproxen, Oxaprozin
Opioids
Agonist–antagonist derivatives	Buprenorphine, Butorphanol, Nalbuphine, Pentazocine
Antagonists	Naloxone
Benzomorphan derivatives	Pentazocine
Centrally acting analgesics	Tramadol
Meperidine-like agonists	Fentanyl, Meperidine
Methadone-like agonists	Methadone, Propoxyphene
Morphine-like agonists	Codeine, Hydrocodone, Hydromorphone, Levorphanol, Morphine, Oxycodone, Oxymorphone
Natural cannabinoids	Tetrahydrocannabinol, Cannabidiol
Synthetic cannabinoids	Dronabinol, Nabilone