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. 2014 Jul 5;7:221–239. doi: 10.2147/CEG.S62831

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© 2014 Berlanga et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Mechanisms of CB1 involved in hepatic lipid accumulation.

Notes: The activation of CB1 receptors in adipose tissue promotes LPL activity, which results in increased FFA release into the liver. The activation of hepatic CB1 receptors contributes to liver fat accumulation by increased de novo hepatic lipogenesis, decreased FA oxidation, and decreased secretion of TG-rich VLDL.

Abbreviations: ACC1, acetyl-CoA carboxylase; CB, cannabinoid; CPT1, carnitine palmitoyltransferase-1; FA, fatty acid; FAS, fatty acid synthase; FFA, free fatty acid; LPL, lipoprotein lipase; SREBP1c, sterol regulatory element-binding protein 1c; TG, triglyceride; VLDL, very-low-density lipoprotein.