Table 2.
Comparisons of treatment-course related characteristics of study population at the end of therapy by new or previously treated status (n = 669)
| Variables (n) | New case | Previously treated case | P -value |
|---|---|---|---|
| Number of significant regimen change |
|
|
|
| 0 |
194 (86.6) |
311 (69.9) |
<0.001 |
| ≥1 |
30 (13.4) |
134 (30.1) |
|
| Elevation of total bilirubin |
|
|
|
| No |
143 (63.8) |
307 (69.0) |
0.180 |
| Yes |
81 (36.2) |
138 (31.0) |
|
| Elevation of liver enzyme |
|
|
|
| No |
181 (80.8) |
365 (82.0) |
0.701 |
| Yes |
43 (19.2) |
80 (18.0) |
|
| Months to treatment completion, median (IQR) |
9.45 (8.89-12.23) |
14.97 (9.67-26.10) |
<0.001† |
| Treatment outcome at EOT |
|
|
|
| Cured |
154 (68.8) |
181 (40.7) |
<0.001* |
| Failure |
4 (1.8) |
61 (13.7) |
|
| TI |
35 (15.6) |
87 (19.6) |
|
| Unknown |
15 (6.7) |
50 (11.2) |
|
| Death |
6 (2.7) |
44 (9.9) |
|
| Withdrawal |
10 (4.5) |
22 (4.9) |
|
| Culture positivity (since enrollment) |
|
|
|
| Converted prior to 6 months |
145 (64.7) |
245 (55.1) |
0.001 |
| Positivity at 6 months, over |
14 (6.2) |
71 (16.0) |
|
| Unknown 6 month result |
65 (29.0) |
129 (29.0) |
|
| Months to TI, median (IQR) | 7.98 (5.02-10.32) | 9.67 (6.60-17.83) | 0.013† |
*Tested by Fisher’s exact test.
† Tested by Mann-Whitney test.
AFB: Acid fast bacilli; IQR: Interquartile range; EOT: End of therapy; TI: Treatment interruption.