Table 2.
Concentrations of total carnitine and its precursors (BB and TML) in plasma, liver and gastrocnemius muscle of lean rats (Lean), obese Zucker rats fed a control diet (Obese Control) or obese Zucker rats fed a diet supplemented with 780 mg niacin/kg diet (Obese Niacin) for 4 wk 1
| Lean | Obese control | Obese niacin | |
|---|---|---|---|
|
Plasma (μmol/l) |
|
|
|
| Total Carnitine |
62.4 ± 2.1a |
39.5 ± 1.1c |
48.4 ± 2.9b |
| γ-Butyrobetaine (BB) |
0.75 ± 0.04a |
0.36 ± 0.04b |
0.42 ± 0.05b |
| Trimethyllysine (TML) |
0.89 ± 0.03a |
0.64 ± 0.02b |
0.67 ± 0.03b |
|
Skeletal muscle (nmol/g) |
|
|
|
| Total Carnitine |
730 ± 26a |
602 ± 28b |
681 ± 28a |
| γ-Butyrobetaine (BB) |
10.9 ± 0.5a |
8.42 ± 0.40ab |
7.31 ± 0.65b |
| Trimethyllysine (TML) |
73.7 ± 11.5 |
58.7 ± 10.5 |
58.8 ± 3.8 |
|
Liver (nmol/g) |
|
|
|
| Total Carnitine |
289 ± 10b |
298 ± 7b |
334 ± 12a |
| γ-Butyrobetaine (BB) |
3.32 ± 0.35a |
2.12 ± 0.13b |
1.93 ± 0.17b |
| Trimethyllysine (TML) | 16.5 ± 1.6 | 13.5 ± 0.7 | 14.1 ± 0.8 |
1Data are expressed as means ± SEM. n = 10 rats/group. a,bValues with different superscript letters differ, P < 0.05.