Table 1.
Prevalence of single nucleotide polymorphism in Pfdhfr and Pfdhps per site
| |
|
DHFR prevalence per site |
DHPS prevalence per site |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CODON | 16 | 50 | 51 | 59 | 108 | 164 | S436A/F/H | 437 | 540 | 581 | 613 | |
| |
|
% (n) |
% (n) |
% (n) |
% (n) |
% (n) |
% (n) |
% (n) |
% (n) |
% (n) |
% (n) |
% (n) |
| KDH |
WILD |
100 (266) |
100 (289) |
1.4 (4) |
3.5 (10) |
0.3 (1) |
98.7 (302) |
100 (256) |
1.5 (4) |
7.5 (21) |
97.2 (273) |
100 (284) |
| MUTANT |
0 (0) |
0 (0) |
96.9 (279) |
92.7 (267) |
99.6 (296) |
1 (3) |
0 (0) |
98.1 (264) |
91.1 (256) |
0.4 (1) |
0 (0) |
|
| MIXED |
0 (0) |
0 (0) |
1.7 (5) |
3.8 (11) |
0 (0) |
0.3 (1) |
0.4 (1) |
0.4 (1) |
1.4 (4) |
2.5 (7) |
0 (0) |
|
| KSI |
WILD |
100 (152) |
100 (155) |
1.3 (2) |
11.0 (17) |
0 (0) |
98.1 (155) |
100 (87) |
1.1 (1) |
9.9 (14) |
96.7 (146) |
100 (117) |
| MUTANT |
0 (0) |
0 (0) |
96.9 (152) |
82.5 (127) |
100 (156) |
1.32 (2) |
0 (0) |
97.9 (91) |
89.4 (126) |
2.0 (3) |
0 (0) |
|
| MIXED |
0 (0) |
0 (0) |
1.9 (3) |
6.5 (10) |
0 (0) |
0.6 (1) |
0 (0) |
1.1 (1) |
0.7 (1) |
1.3 (2) |
0 (0) |
|
| KCH |
WILD |
100 (93) |
100 (93) |
2.2 (2) |
7.7 (6) |
2.1 (2) |
100 (93) |
98.9 (89) |
2.2 (2) |
3.8 (4) |
98.1 (102) |
100 (104) |
| MUTANT |
0 (0) |
0 (0) |
97.9 (91) |
73.1 (57) |
97.9 (92) |
0 (0) |
0 (0) |
96.7 (87) |
90.4 (94) |
1.0 (1) |
0 (0) |
|
| MIXED |
0 (0) |
0 (0) |
0 (0) |
19.2 (15) |
0 (0) |
0 (0) |
1.1 (1) |
1.1 (1) |
5.8 (6) |
1.0 (1) |
0 (0) |
|
| MDH | WILD |
100 (99) |
100 (103) |
10.7 (11) |
24.3 (25) |
5.8 (6) |
100 (103) |
98.9 (98) |
13.2 (14) |
11.9 (12) |
100 (104) |
100 (107) |
| MUTANT |
0 (0) |
0 (0) |
87.4 (90) |
70.9 (73) |
94.2 (97) |
0 (0) |
1.0 (1) |
86.8 (92) |
86.1 (87) |
0 (0) |
0 (0) |
|
| MIXED | 0 (0) | 0 (0) | 1.9 (2) | 4.9 (5) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 2.0 (2) | 0 (0) | 0 (0) | |
Prevalence of Pfdhfr and Pfdhps wildtype, mutant and mixed genotypes per study site for the entire period was calculated as a percentage of the total number of samples successfully analysed over the study period per codon per the specific site.