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. 2014 Jun 4;103(2):281–290. doi: 10.1093/cvr/cvu142

Figure 2.

Figure 2

Characterization of mice with vascular cell-specific AR deletion. Cell-specific AR deletion was confirmed (A; n = 4 for each genotype) using PCR on genomic DNA from freshly isolated aortic EC and SMC. Mouse genotypes were confirmed (B) with PCR using genomic DNA from ear clip samples. Deletion of vascular AR did not alter circulating testosterone levels (C; n = 14–23) or seminal vesicle weight (D; n = 8–15) but deletion of AR from EC (VE-ARKO) produced a small increase in systolic blood pressure (E). *P < 0.05 (n = 7–12) by one-way ANOVA plus Bonferroni post-hoc test. (WT = wild-type litter mates carrying floxed-AR; SM-ARKO = AR ablated in SMC, VE-ARKO = AR ablated in EC, SM/VE-ARKO = AR ablated in both EC and SMC.)