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. 2014 Jun 4;103(2):281–290. doi: 10.1093/cvr/cvu142

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© The Author 2014. Published by Oxford University Press on behalf of the European Society of Cardiology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Testosterone induces relaxation in vascular ARKO arteries. Supra-physiological concentration of testosterone induced vascular relaxation both in femoral (A) and mesenteric (B) arteries from all genotypes, which was independent of the type of pre-constriction. Vascular ARKO produced no dramatic changes in testosterone-mediated relaxation despite some small differences in relaxation at specific concentrations. *P < 0.05, **P < 0.01 vs. corresponding WT concentration; ^#P < 0.05 vs. corresponding VE-ARKO concentration; two-way ANOVA plus Bonferroni post-hoc test. (WT = wild-type litter mates carrying floxed-AR; SM-ARKO = AR ablated in SMC, VE-ARKO = AR ablated in EC, SM/VE-ARKO = AR ablated in both EC and SMC. n = 7–9.)