Figure 6.

Castration increases neointimal lesion formation following wire injury but not following arterial ligation. In arteries subjected to either (A) wire-induced injury or (B) ligation, neointimal lesion distribution (i) and neointimal volume (ii) were determined by OPT. Maximal cross-sectional narrowing (iii) was measured in serial sections stained with Masson's trichrome. Panels A(i) and B(i) show mean neointimal lesion volumes for each group; error bars have been omitted for clarity. Panels A(ii & iii) and B(ii & iii) show individual data points from each animal in the group with lines and error bars indicating mean ± SEM. *P < 0.05, by Student's t-test (A: n = 8–10; B: n = 6–8 ).