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Pharmacophore model of BChE inhibitors generated by HYPOREFINE. (a) The best HYPOREFINE model Hypo1_B. (b) Hypo1_B mapping with one of the most active compound 17 (IC50 = 3.3 nM). Pharmacophore features are color-coded with blue for hydrophobic feature, orange for ring aromatic feature, green for hydrogen-bond acceptor, and grey for excluded volumes.
