Table 3.
Risk of Hematological Malignancies among Individuals with AUDs by Age at Identification.
Disease |
< 40 |
40-60 |
60 + |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
O | SIR | 95% CI | O | SIR | 95% CI | O | SIR | 95% CI | ||||
Non-Hodgkin lymphoma | 150 | 0.97 | 0.82 | 1.13 | 420 | 0.72 | 0.65 | 0.79 | 371 | 0.53 | 0.47 | 0.58 |
Diffuse large B cell | 28 | 1.34 | 0.89 | 1.94 | 68 | 0.96 | 0.75 | 1.22 | 35 | 0.57 | 0.40 | 0.79 |
Follicular | 9 | 0.93 | 0.42 | 1.77 | 34 | 0.77 | 0.53 | 1.08 | 19 | 0.59 | 0.36 | 0.93 |
Hodgkin disease | 102 | 0.92 | 0.75 | 1.11 | 97 | 0.73 | 0.59 | 0.89 | 26 | 0.36 | 0.23 | 0.52 |
Mixed cellularity classic | 9 | 1.05 | 0.48 | 2.00 | 7 | 0.95 | 0.38 | 1.97 | 2 | 0.49 | 0.05 | 1.82 |
Nodular sclerosis classic | 44 | 1.10 | 0.80 | 1.47 | 19 | 1.20 | 0.72 | 1.88 | 7 | 1.23 | 0.49 | 2.56 |
Myeloma | 15 | 0.98 | 0.55 | 1.62 | 104 | 0.77 | 0.63 | 0.94 | 77 | 0.34 | 0.27 | 0.43 |
Leukemia | 120 | 0.61 | 0.50 | 0.72 | 160 | 0.55 | 0.47 | 0.65 | 113 | 0.40 | 0.33 | 0.48 |
Acute lymphatic leukemia | 59 | 0.62 | 0.47 | 0.80 | 12 | 0.37 | 0.19 | 0.64 | 1 | 0.06 | 0.00 | 0.37 |
Acute myeloid leukemia | 20 | 0.57 | 0.35 | 0.88 | 25 | 0.29 | 0.19 | 0.43 | 18 | 0.19 | 0.11 | 0.30 |
Chronic myeloid leukemia | 19 | 0.80 | 0.48 | 1.25 | 26 | 0.49 | 0.32 | 0.72 | 18 | 0.45 | 0.26 | 0.71 |
All | 387 | 0.81 | 0.73 | 0.89 | 781 | 0.68 | 0.64 | 0.73 | 587 | 0.46 | 0.42 | 0.49 |
O, observed number of cases; SIR, standardized incidence ratio; CI, confidence interval.
Bold type, 95% CI does not include 1.00.