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. 2014 Apr 13;16(3):265–278.e13. doi: 10.1016/j.neo.2014.03.001

Table W1.

ANOVA analysis (post-hoc testing) for statistics of figures.

Multiple Comparisons
(I) 1 = low risk,2 = intermediate risk,3 = high risk (J) 1 = low risk,2 = intermediate risk,3 = high risk Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 1A
1 2 − 1.53243* .57014 .031 − 2.9405 -.1244
3 − 1.47190* .58777 .046 − 2.9235 -.0203
2 1 1.53243* .57014 .031 .1244 2.9405
3 .06053 .62280 .995 − 1.4776 1.5986
3 1 1.47190* .58777 .046 .0203 2.9235
2 -.06053 .62280 .995 − 1.5986 1.4776
VAR00001
Tukey HSD



Multiple Comparisons
(I) concentration (J) concentration Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 3B
Day0
0 1 -.0040000 .0094810 .973 -.034361 .026361
20 -.0160000 .0094810 .389 -.046361 .014361
50 -.0013333 .0094810 .999 -.031695 .029028
1 0 .0040000 .0094810 .973 -.026361 .034361
20 -.0120000 .0094810 .607 -.042361 .018361
50 .0026667 .0094810 .992 -.027695 .033028
20 0 .0160000 .0094810 .389 -.014361 .046361
1 .0120000 .0094810 .607 -.018361 .042361
50 .0146667 .0094810 .456 -.015695 .045028
50 0 .0013333 .0094810 .999 -.029028 .031695
1 -.0026667 .0094810 .992 -.033028 .027695
20 -.0146667 .0094810 .456 -.045028 .015695
VAR00001
Tukey HSD



Multiple Comparisons
(I) concentration (J) concentration Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 3B
Day1
0 1 .0023333 .0055578 .973 -.015465 .020131
20 -.0216667* .0055578 .019 -.039465 -.003869
50 -.0230000* .0055578 .014 -.040798 -.005202
1 0 -.0023333 .0055578 .973 -.020131 .015465
20 -.0240000* .0055578 .011 -.041798 -.006202
50 -.0253333* .0055578 .008 -.043131 -.007535
20 0 .0216667* .0055578 .019 .003869 .039465
1 .0240000* .0055578 .011 .006202 .041798
50 -.0013333 .0055578 .995 -.019131 .016465
50 0 .0230000* .0055578 .014 .005202 .040798
1 .0253333* .0055578 .008 .007535 .043131
20 .0013333 .0055578 .995 -.016465 .019131
VAR00001
Tukey HSD



Multiple Comparisons
(I) concentration (J) concentration Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 3B
Day2
0 1 -.0596667* .0133083 .009 -.102285 -.017049
20 -.0253333 .0133083 .299 -.067951 .017285
50 -.0746667* .0133083 .002 -.117285 -.032049
1 0 .0596667* .0133083 .009 .017049 .102285
20 .0343333 .0133083 .120 -.008285 .076951
50 -.0150000 .0133083 .684 -.057618 .027618
20 0 .0253333 .0133083 .299 -.017285 .067951
1 -.0343333 .0133083 .120 -.076951 .008285
50 -.0493333* .0133083 .025 -.091951 -.006715
50 0 .0746667* .0133083 .002 .032049 .117285
1 .0150000 .0133083 .684 -.027618 .057618
20 .0493333* .0133083 .025 .006715 .091951
VAR00001
Tukey HSD



Multiple Comparisons
(I) concentration (J) concentration Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 3B
Day3
0 1 -.0046667 .0051962 .806 -.021307 .011973
20 -.0223333* .0051962 .011 -.038973 -.005693
50 -.0283333* .0051962 .003 -.044973 -.011693
1 0 .0046667 .0051962 .806 -.011973 .021307
20 -.0176667* .0051962 .038 -.034307 -.001027
50 -.0236667* .0051962 .008 -.040307 -.007027
20 0 .0223333* .0051962 .011 .005693 .038973
1 .0176667* .0051962 .038 .001027 .034307
50 -.0060000 .0051962 .669 -.022640 .010640
50 0 .0283333* .0051962 .003 .011693 .044973
1 .0236667* .0051962 .008 .007027 .040307
20 .0060000 .0051962 .669 -.010640 .022640
VAR00001
Tukey HSD



Multiple Comparisons
(I) concentration (J) concentration Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 3B
Day4
0 1 -.0030000 .0072111 .974 -.026092 .020092
20 .0173333 .0072111 .154 -.005759 .040426
50 -.0753333* .0072111 .000 -.098426 -.052241
1 0 .0030000 .0072111 .974 -.020092 .026092
20 .0203333 .0072111 .086 -.002759 .043426
50 -.0723333* .0072111 .000 -.095426 -.049241
20 0 -.0173333 .0072111 .154 -.040426 .005759
1 -.0203333 .0072111 .086 -.043426 .002759
50 -.0926667* .0072111 .000 -.115759 -.069574
50 0 .0753333* .0072111 .000 .052241 .098426
1 .0723333* .0072111 .000 .049241 .095426
20 .0926667* .0072111 .000 .069574 .115759
VAR00001
Tukey HSD



Multiple Comparisons
(I) concentration (J) concentration Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 3B
Day5
0 1 .0146667 .0078916 .316 -.010605 .039938
20 -.0660000* .0078916 .000 -.091272 -.040728
50 -.0893333* .0078916 .000 -.114605 -.064062
1 0 -.0146667 .0078916 .316 -.039938 .010605
20 -.0806667* .0078916 .000 -.105938 -.055395
50 -.1040000* .0078916 .000 -.129272 -.078728
20 0 .0660000* .0078916 .000 .040728 .091272
1 .0806667* .0078916 .000 .055395 .105938
50 -.0233333 .0078916 .071 -.048605 .001938
50 0 .0893333* .0078916 .000 .064062 .114605
1 .1040000* .0078916 .000 .078728 .129272
20 .0233333 .0078916 .071 -.001938 .048605
VAR00001
Tukey HSD



Multiple Comparisons
(I) concentration (J) concentration Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 3B
Day6
0 1 -.0046667 .0106797 .970 -.038867 .029533
20 -.0750000* .0106797 .001 -.109200 -.040800
50 -.1590000* .0106797 .000 -.193200 -.124800
1 0 .0046667 .0106797 .970 -.029533 .038867
20 -.0703333* .0106797 .001 -.104533 -.036133
50 -.1543333* .0106797 .000 -.188533 -.120133
20 0 .0750000* .0106797 .001 .040800 .109200
1 .0703333* .0106797 .001 .036133 .104533
50 -.0840000* .0106797 .000 -.118200 -.049800
50 0 .1590000* .0106797 .000 .124800 .193200
1 .1543333* .0106797 .000 .120133 .188533
20 .0840000* .0106797 .000 .049800 .118200
VAR00001
Tukey HSD



Multiple Comparisons
(I) VAR00002 (J) VAR00002 Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 3C
0 1 − 6.50000* 1.69558 .005 − 11.2458 − 1.7542
20 − 55.50000* 1.69558 .000 − 60.2458 − 50.7542
50 − 69.16667* 1.69558 .000 − 73.9125 − 64.4208
1 0 6.50000* 1.69558 .005 1.7542 11.2458
20 − 49.00000* 1.69558 .000 − 53.7458 − 44.2542
50 − 62.66667* 1.69558 .000 − 67.4125 − 57.9208
20 0 55.50000* 1.69558 .000 50.7542 60.2458
1 49.00000* 1.69558 .000 44.2542 53.7458
50 − 13.66667* 1.69558 .000 − 18.4125 − 8.9208
50 0 69.16667* 1.69558 .000 64.4208 73.9125
1 62.66667* 1.69558 .000 57.9208 67.4125
20 13.66667* 1.69558 .000 8.9208 18.4125
VAR00001
Tukey HSD



Multiple Comparisons
(I) concentration (J) concentration Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 3D
0 1 − 23.66667* 3.28549 .000 − 32.8625 − 14.4708
20 − 55.50000* 3.28549 .000 − 64.6959 − 46.3041
50 − 72.16667* 3.28549 .000 − 81.3625 − 62.9708
1 0 23.66667* 3.28549 .000 14.4708 32.8625
20 − 31.83333* 3.28549 .000 − 41.0292 − 22.6375
50 − 48.50000* 3.28549 .000 − 57.6959 − 39.3041
20 0 55.50000* 3.28549 .000 46.3041 64.6959
1 31.83333* 3.28549 .000 22.6375 41.0292
50 − 16.66667* 3.28549 .000 − 25.8625 − 7.4708
50 0 72.16667* 3.28549 .000 62.9708 81.3625
1 48.50000* 3.28549 .000 39.3041 57.6959
20 16.66667* 3.28549 .000 7.4708 25.8625
VAR00001
Tukey HSD



Multiple Comparisons
(I) VAR00002 (J) VAR00002 Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 4A (Mutant TCF)
0 1 -.01200 .02143 .941 -.0806 .0566
20 -.02933 .02143 .550 -.0980 .0393
50 -.04333 .02143 .257 -.1120 .0253
1 0 .01200 .02143 .941 -.0566 .0806
20 -.01733 .02143 .849 -.0860 .0513
50 -.03133 .02143 .500 -.1000 .0373
20 0 .02933 .02143 .550 -.0393 .0980
1 .01733 .02143 .849 -.0513 .0860
50 -.01400 .02143 .911 -.0826 .0546
50 0 .04333 .02143 .257 -.0253 .1120
1 .03133 .02143 .500 -.0373 .1000
20 .01400 .02143 .911 -.0546 .0826
VAR00001
Tukey HSD



Multiple Comparisons
(I) VAR00002 (J) VAR00002 Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 4A (TCF)
0 1 .19167* .02076 .000 .1252 .2582
20 .30900* .02076 .000 .2425 .3755
50 .46600* .02076 .000 .3995 .5325
1 0 -.19167* .02076 .000 -.2582 -.1252
20 .11733* .02076 .002 .0508 .1838
50 .27433* .02076 .000 .2078 .3408
20 0 -.30900* .02076 .000 -.3755 -.2425
1 -.11733* .02076 .002 -.1838 -.0508
50 .15700* .02076 .000 .0905 .2235
50 0 -.46600* .02076 .000 -.5325 -.3995
1 -.27433* .02076 .000 -.3408 -.2078
20 -.15700* .02076 .000 -.2235 -.0905
VAR00001
Tukey HSD



Multiple Comparisons
(I) VAR00002 (J) VAR00002 Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 4B
0 1 − 1.92467* .41532 .007 − 3.2547 -.5947
20 − 2.50733* .41532 .001 − 3.8373 − 1.1773
50 − 6.96000* .41532 .000 − 8.2900 − 5.6300
1 0 1.92467* .41532 .007 .5947 3.2547
20 -.58267 .41532 .531 − 1.9127 .7473
50 − 5.03533* .41532 .000 − 6.3653 − 3.7053
20 0 2.50733* .41532 .001 1.1773 3.8373
1 .58267 .41532 .531 -.7473 1.9127
50 − 4.45267* .41532 .000 − 5.7827 − 3.1227
50 0 6.96000* .41532 .000 5.6300 8.2900
1 5.03533* .41532 .000 3.7053 6.3653
20 4.45267* .41532 .000 3.1227 5.7827
VAR00001
Tukey HSD



Multiple Comparisons
(I) 1 = 0nm,2 = 20nm,3 = 0nm+Wnt5a mAb,4 = 20nm+Wnt5a mAb (J) 1 = 0nm,2 = 20nm,3 = 0nm+Wnt5a mAb,4 = 20nm+Wnt5a mAb Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 4C
1 2 .33467* .03334 .000 .2279 .4414
3 .04400 .03334 .577 -.0628 .1508
4 .16100* .03334 .006 .0542 .2678
2 1 -.33467* .03334 .000 -.4414 -.2279
3 -.29067* .03334 .000 -.3974 -.1839
4 -.17367* .03334 .004 -.2804 -.0669
3 1 -.04400 .03334 .577 -.1508 .0628
2 .29067* .03334 .000 .1839 .3974
4 .11700* .03334 .033 .0102 .2238
4 1 -.16100* .03334 .006 -.2678 -.0542
2 .17367* .03334 .004 .0669 .2804
3 -.11700* .03334 .033 -.2238 -.0102
VAR00001
Tukey HSD



Multiple Comparisons
(I) VAR00002 (J) VAR00002 Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 4D
1 2 − 2.75433* .27391 .000 − 3.6315 − 1.8772
3 1.07233* .27391 .019 .1952 1.9495
4 -.32100 .27391 .659 − 1.1981 .5561
2 1 2.75433* .27391 .000 1.8772 3.6315
3 3.82667* .27391 .000 2.9495 4.7038
4 2.43333* .27391 .000 1.5562 3.3105
3 1 − 1.07233* .27391 .019 − 1.9495 -.1952
2 − 3.82667* .27391 .000 − 4.7038 − 2.9495
4 − 1.39333* .27391 .004 − 2.2705 -.5162
4 1 .32100 .27391 .659 -.5561 1.1981
2 − 2.43333* .27391 .000 − 3.3105 − 1.5562
3 1.39333* .27391 .004 .5162 2.2705
VAR00001
Tukey HSD



Multiple Comparisons
(I) 1 = NC,2 = + Wnt3a,3 = + Wnt3a mAb,4 = Wnt3a+Wnt3a mAb (J) 1 = NC,2 = + Wnt3a,3 = + Wnt3a mAb,4 = Wnt3a+Wnt3a mAb Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 4E
1 2 -.47433* .04523 .000 -.6192 -.3295
3 .17733* .04523 .019 .0325 .3222
4 .16567* .04523 .026 .0208 .3105
2 1 .47433* .04523 .000 .3295 .6192
3 .65167* .04523 .000 .5068 .7965
4 .64000* .04523 .000 .4951 .7849
3 1 -.17733* .04523 .019 -.3222 -.0325
2 -.65167* .04523 .000 -.7965 -.5068
4 -.01167 .04523 .994 -.1565 .1332
4 1 -.16567* .04523 .026 -.3105 -.0208
2 -.64000* .04523 .000 -.7849 -.4951
3 .01167 .04523 .994 -.1332 .1565
VAR00001
Tukey HSD



Multiple Comparisons
(I) 1 = NC,2 = + Wnt5a,3 = + Wnt5a mAb,4 = Wnt5a+Wnt5a mAb (J) 1 = NC,2 = + Wnt5a,3 = + Wnt5a mAb,4 = Wnt5a+Wnt5a mAb Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 4F
1 2 − 3.02767* .20239 .000 − 3.6758 − 2.3795
3 1.02867* .20239 .004 .3805 1.6768
4 -.17100 .20239 .832 -.8191 .4771
2 1 3.02767* .20239 .000 2.3795 3.6758
3 4.05633* .20239 .000 3.4082 4.7045
4 2.85667* .20239 .000 2.2085 3.5048
3 1 − 1.02867* .20239 .004 − 1.6768 -.3805
2 − 4.05633* .20239 .000 − 4.7045 − 3.4082
4 − 1.19967* .20239 .002 − 1.8478 -.5515
4 1 .17100 .20239 .832 -.4771 .8191
2 − 2.85667* .20239 .000 − 3.5048 − 2.2085
3 1.19967* .20239 .002 .5515 1.8478
VAR00001
Tukey HSD



Multiple Comparisons
(I) VAR00002 (J) VAR00002 Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 5B
0 5 -.58300* .05290 .000 -.7571 -.4089
10 -.12600 .05290 .197 -.3001 .0481
30 -.40433* .05290 .000 -.5784 -.2302
60 -.13600 .05290 .150 -.3101 .0381
5 0 .58300* .05290 .000 .4089 .7571
10 .45700* .05290 .000 .2829 .6311
30 .17867* .05290 .044 .0046 .3528
60 .44700* .05290 .000 .2729 .6211
10 0 .12600 .05290 .197 -.0481 .3001
5 -.45700* .05290 .000 -.6311 -.2829
30 -.27833* .05290 .003 -.4524 -.1042
60 -.01000 .05290 1.000 -.1841 .1641
30 0 .40433* .05290 .000 .2302 .5784
5 -.17867* .05290 .044 -.3528 -.0046
10 .27833* .05290 .003 .1042 .4524
60 .26833* .05290 .003 .0942 .4424
60 0 .13600 .05290 .150 -.0381 .3101
5 -.44700* .05290 .000 -.6211 -.2729
10 .01000 .05290 1.000 -.1641 .1841
30 -.26833* .05290 .003 -.4424 -.0942
VAR00001
Tukey HSD



Multiple Comparisons
(I) VAR00002 (J) VAR00002 Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 5C
0 5 -.20667* .01588 .000 -.2589 -.1544
10 -.39767* .01588 .000 -.4499 -.3454
30 -.52167* .01588 .000 -.5739 -.4694
60 -.53733* .01588 .000 -.5896 -.4851
5 0 .20667* .01588 .000 .1544 .2589
10 -.19100* .01588 .000 -.2433 -.1387
30 -.31500* .01588 .000 -.3673 -.2627
60 -.33067* .01588 .000 -.3829 -.2784
10 0 .39767* .01588 .000 .3454 .4499
5 .19100* .01588 .000 .1387 .2433
30 -.12400* .01588 .000 -.1763 -.0717
60 -.13967* .01588 .000 -.1919 -.0874
30 0 .52167* .01588 .000 .4694 .5739
5 .31500* .01588 .000 .2627 .3673
10 .12400* .01588 .000 .0717 .1763
60 -.01567 .01588 .855 -.0679 .0366
60 0 .53733* .01588 .000 .4851 .5896
5 .33067* .01588 .000 .2784 .3829
10 .13967* .01588 .000 .0874 .1919
30 .01567 .01588 .855 -.0366 .0679
VAR00001
Tukey HSD



Multiple Comparisons
(I) time (J) time Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 5D
0 5 .03000 .03961 .937 -.1004 .1604
10 -.01000 .03961 .999 -.1404 .1204
30 .00667 .03961 1.000 -.1237 .1370
60 -.02333 .03961 .974 -.1537 .1070
5 0 -.03000 .03961 .937 -.1604 .1004
10 -.04000 .03961 .845 -.1704 .0904
30 -.02333 .03961 .974 -.1537 .1070
60 -.05333 .03961 .671 -.1837 .0770
10 0 .01000 .03961 .999 -.1204 .1404
5 .04000 .03961 .845 -.0904 .1704
30 .01667 .03961 .992 -.1137 .1470
60 -.01333 .03961 .997 -.1437 .1170
30 0 -.00667 .03961 1.000 -.1370 .1237
5 .02333 .03961 .974 -.1070 .1537
10 -.01667 .03961 .992 -.1470 .1137
60 -.03000 .03961 .937 -.1604 .1004
60 0 .02333 .03961 .974 -.1070 .1537
5 .05333 .03961 .671 -.0770 .1837
10 .01333 .03961 .997 -.1170 .1437
30 .03000 .03961 .937 -.1004 .1604
VAR00001
Tukey HSD



Multiple Comparisons
(I) VAR00002 (J) VAR00002 Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 5E
0 1 -.11033* .02696 .015 -.1967 -.0240
20 -.32633* .02696 .000 -.4127 -.2400
50 -.47333* .02696 .000 -.5597 -.3870
1 0 .11033* .02696 .015 .0240 .1967
20 -.21600* .02696 .000 -.3023 -.1297
50 -.36300* .02696 .000 -.4493 -.2767
20 0 .32633* .02696 .000 .2400 .4127
1 .21600* .02696 .000 .1297 .3023
50 -.14700* .02696 .003 -.2333 -.0607
50 0 .47333* .02696 .000 .3870 .5597
1 .36300* .02696 .000 .2767 .4493
20 .14700* .02696 .003 .0607 .2333
VAR00001
Tukey HSD



Multiple Comparisons
(I) VAR00002 (J) VAR00002 Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 5F
0 1 -.15167* .01790 .000 -.2090 -.0943
20 -.39267* .01790 .000 -.4500 -.3353
50 -.51900* .01790 .000 -.5763 -.4617
1 0 .15167* .01790 .000 .0943 .2090
20 -.24100* .01790 .000 -.2983 -.1837
50 -.36733* .01790 .000 -.4247 -.3100
20 0 .39267* .01790 .000 .3353 .4500
1 .24100* .01790 .000 .1837 .2983
50 -.12633* .01790 .000 -.1837 -.0690
50 0 .51900* .01790 .000 .4617 .5763
1 .36733* .01790 .000 .3100 .4247
20 .12633* .01790 .000 .0690 .1837
VAR00001
Tukey HSD



Multiple Comparisons
(I) VAR00002 (J) VAR00002 Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 6C
0 5 -.08967* .02012 .008 -.1559 -.0234
10 -.37167* .02012 .000 -.4379 -.3054
30 -.56933* .02012 .000 -.6356 -.5031
60 -.74133* .02012 .000 -.8076 -.6751
5 0 .08967* .02012 .008 .0234 .1559
10 -.28200* .02012 .000 -.3482 -.2158
30 -.47967* .02012 .000 -.5459 -.4134
60 -.65167* .02012 .000 -.7179 -.5854
10 0 .37167* .02012 .000 .3054 .4379
5 .28200* .02012 .000 .2158 .3482
30 -.19767* .02012 .000 -.2639 -.1314
60 -.36967* .02012 .000 -.4359 -.3034
30 0 .56933* .02012 .000 .5031 .6356
5 .47967* .02012 .000 .4134 .5459
10 .19767* .02012 .000 .1314 .2639
60 -.17200* .02012 .000 -.2382 -.1058
60 0 .74133* .02012 .000 .6751 .8076
5 .65167* .02012 .000 .5854 .7179
10 .36967* .02012 .000 .3034 .4359
30 .17200* .02012 .000 .1058 .2382
VAR00001
Tukey HSD



Multiple Comparisons
(I) time (J) time Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 6D
0 5 -.23467* .02028 .000 -.3014 -.1679
10 -.82533* .02028 .000 -.8921 -.7586
30 -.68733* .02028 .000 -.7541 -.6206
60 -.46233* .02028 .000 -.5291 -.3956
5 0 .23467* .02028 .000 .1679 .3014
10 -.59067* .02028 .000 -.6574 -.5239
30 -.45267* .02028 .000 -.5194 -.3859
60 -.22767* .02028 .000 -.2944 -.1609
10 0 .82533* .02028 .000 .7586 .8921
5 .59067* .02028 .000 .5239 .6574
30 .13800* .02028 .000 .0712 .2048
60 .36300* .02028 .000 .2962 .4298
30 0 .68733* .02028 .000 .6206 .7541
5 .45267* .02028 .000 .3859 .5194
10 -.13800* .02028 .000 -.2048 -.0712
60 .22500* .02028 .000 .1582 .2918
60 0 .46233* .02028 .000 .3956 .5291
5 .22767* .02028 .000 .1609 .2944
10 -.36300* .02028 .000 -.4298 -.2962
30 -.22500* .02028 .000 -.2918 -.1582
VAR00001
Tukey HSD



Multiple Comparisons
(I) time (J) time Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 6E
0 5 .02467 .02220 .797 -.0484 .0977
10 -.33967* .02220 .000 -.4127 -.2666
30 -.26100* .02220 .000 -.3341 -.1879
60 -.37767* .02220 .000 -.4507 -.3046
5 0 -.02467 .02220 .797 -.0977 .0484
10 -.36433* .02220 .000 -.4374 -.2913
30 -.28567* .02220 .000 -.3587 -.2126
60 -.40233* .02220 .000 -.4754 -.3293
10 0 .33967* .02220 .000 .2666 .4127
5 .36433* .02220 .000 .2913 .4374
30 .07867* .02220 .034 .0056 .1517
60 -.03800 .02220 .469 -.1111 .0351
30 0 .26100* .02220 .000 .1879 .3341
5 .28567* .02220 .000 .2126 .3587
10 -.07867* .02220 .034 -.1517 -.0056
60 -.11667* .02220 .003 -.1897 -.0436
60 0 .37767* .02220 .000 .3046 .4507
5 .40233* .02220 .000 .3293 .4754
10 .03800 .02220 .469 -.0351 .1111
30 .11667* .02220 .003 .0436 .1897
data
Tukey HSD



Multiple Comparisons
(I) time (J) time Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 6F
0 5 -.43533* .01941 .000 -.4992 -.3715
10 -.83733* .01941 .000 -.9012 -.7735
30 -.77067* .01941 .000 -.8345 -.7068
60 -.78267* .01941 .000 -.8465 -.7188
5 0 .43533* .01941 .000 .3715 .4992
10 -.40200* .01941 .000 -.4659 -.3381
30 -.33533* .01941 .000 -.3992 -.2715
60 -.34733* .01941 .000 -.4112 -.2835
10 0 .83733* .01941 .000 .7735 .9012
5 .40200* .01941 .000 .3381 .4659
30 .06667* .01941 .040 .0028 .1305
60 .05467 .01941 .104 -.0092 .1185
30 0 .77067* .01941 .000 .7068 .8345
5 .33533* .01941 .000 .2715 .3992
10 -.06667* .01941 .040 -.1305 -.0028
60 -.01200 .01941 .969 -.0759 .0519
60 0 .78267* .01941 .000 .7188 .8465
5 .34733* .01941 .000 .2835 .4112
10 -.05467 .01941 .104 -.1185 .0092
30 .01200 .01941 .969 -.0519 .0759
data
Tukey HSD



Multiple Comparisons
(I) 1 = 0nm,2 = 20nm,3 = 0nm+Wnt3a mAb,4 = 20nm+Wnt3a mAb,5 = 0nm+Wnt5a mAb,6 = 20nm+Wnt5a mAb (J) 1 = 0nm,2 = 20nm,3 = 0nm+Wnt3a mAb,4 = 20nm+Wnt3a mAb,5 = 0nm+Wnt5a mAb,6 = 20nm+Wnt5a mAb Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 7B
1 2 − 53.00000* 4.10916 .000 − 65.4984 − 40.5016
3 -.33333 4.10916 1.000 − 12.8317 12.1651
4 − 49.50000* 4.10916 .000 − 61.9984 − 37.0016
5 − 4.50000 4.10916 .879 − 16.9984 7.9984
6 − 13.33333* 4.10916 .031 − 25.8317 -.8349
2 1 53.00000* 4.10916 .000 40.5016 65.4984
3 52.66667* 4.10916 .000 40.1683 65.1651
4 3.50000 4.10916 .955 − 8.9984 15.9984
5 48.50000* 4.10916 .000 36.0016 60.9984
6 39.66667* 4.10916 .000 27.1683 52.1651
3 1 .33333 4.10916 1.000 − 12.1651 12.8317
2 − 52.66667* 4.10916 .000 − 65.1651 − 40.1683
4 − 49.16667* 4.10916 .000 − 61.6651 − 36.6683
5 − 4.16667 4.10916 .910 − 16.6651 8.3317
6 − 13.00000* 4.10916 .038 − 25.4984 -.5016
4 1 49.50000* 4.10916 .000 37.0016 61.9984
2 − 3.50000 4.10916 .955 − 15.9984 8.9984
3 49.16667* 4.10916 .000 36.6683 61.6651
5 45.00000* 4.10916 .000 32.5016 57.4984
6 36.16667* 4.10916 .000 23.6683 48.6651
5 1 4.50000 4.10916 .879 − 7.9984 16.9984
2 − 48.50000* 4.10916 .000 − 60.9984 − 36.0016
3 4.16667 4.10916 .910 − 8.3317 16.6651
4 − 45.00000* 4.10916 .000 − 57.4984 − 32.5016
6 − 8.83333 4.10916 .290 − 21.3317 3.6651
6 1 13.33333* 4.10916 .031 .8349 25.8317
2 − 39.66667* 4.10916 .000 − 52.1651 − 27.1683
3 13.00000* 4.10916 .038 .5016 25.4984
4 − 36.16667* 4.10916 .000 − 48.6651 − 23.6683
5 8.83333 4.10916 .290 − 3.6651 21.3317
VAR00001
Tukey HSD



Multiple Comparisons
(I) 1 = 0nm,2 = 20nm,3 = 0nm+NSC23766,4 = 20nm+NSC23766,5 = 0nm+Y-27632,6 = 20nm+Y-27632 (J) 1 = 0nm,2 = 20nm,3 = 0nm+NSC23766,4 = 20nm+NSC23766,5 = 0nm+Y-27632,6 = 20nm+Y-27632 Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 7D
1 2 − 51.00000* 2.31541 .000 − 58.0425 − 43.9575
3 − 4.16667 2.31541 .481 − 11.2092 2.8759
4 − 15.50000* 2.31541 .000 − 22.5425 − 8.4575
5 − 7.16667* 2.31541 .044 − 14.2092 -.1241
6 − 11.00000* 2.31541 .001 − 18.0425 − 3.9575
2 1 51.00000* 2.31541 .000 43.9575 58.0425
3 46.83333* 2.31541 .000 39.7908 53.8759
4 35.50000* 2.31541 .000 28.4575 42.5425
5 43.83333* 2.31541 .000 36.7908 50.8759
6 40.00000* 2.31541 .000 32.9575 47.0425
3 1 4.16667 2.31541 .481 − 2.8759 11.2092
2 − 46.83333* 2.31541 .000 − 53.8759 − 39.7908
4 − 11.33333* 2.31541 .000 − 18.3759 − 4.2908
5 − 3.00000 2.31541 .785 − 10.0425 4.0425
6 − 6.83333 2.31541 .061 − 13.8759 .2092
4 1 15.50000* 2.31541 .000 8.4575 22.5425
2 − 35.50000* 2.31541 .000 − 42.5425 − 28.4575
3 11.33333* 2.31541 .000 4.2908 18.3759
5 8.33333* 2.31541 .013 1.2908 15.3759
6 4.50000 2.31541 .397 − 2.5425 11.5425
5 1 7.16667* 2.31541 .044 .1241 14.2092
2 − 43.83333* 2.31541 .000 − 50.8759 − 36.7908
3 3.00000 2.31541 .785 − 4.0425 10.0425
4 − 8.33333* 2.31541 .013 − 15.3759 − 1.2908
6 − 3.83333 2.31541 .570 − 10.8759 3.2092
6 1 11.00000* 2.31541 .001 3.9575 18.0425
2 − 40.00000* 2.31541 .000 − 47.0425 − 32.9575
3 6.83333 2.31541 .061 -.2092 13.8759
4 − 4.50000 2.31541 .397 − 11.5425 2.5425
5 3.83333 2.31541 .570 − 3.2092 10.8759
VAR00001
Tukey HSD



Multiple Comparisons
(I) 1 = 0nm,2 = 20nm,3 = 0nm+Wnt3a mAb,4 = 20nm+Wnt3a mAb,5 = 0nm+Wnt5a mAb,6 = 20nm+Wnt5a mAb (J) 1 = 0nm,2 = 20nm,3 = 0nm+Wnt3a mAb,4 = 20nm+Wnt3a mAb,5 = 0nm+Wnt5a mAb,6 = 20nm+Wnt5a mAb Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 8B
1 2 − 71.83333* 3.48250 .000 − 82.4257 − 61.2410
3 1.00000 3.48250 1.000 − 9.5923 11.5923
4 − 65.33333* 3.48250 .000 − 75.9257 − 54.7410
5 − 1.00000 3.48250 1.000 − 11.5923 9.5923
6 − 9.33333 3.48250 .109 − 19.9257 1.2590
2 1 71.83333* 3.48250 .000 61.2410 82.4257
3 72.83333* 3.48250 .000 62.2410 83.4257
4 6.50000 3.48250 .441 − 4.0923 17.0923
5 70.83333* 3.48250 .000 60.2410 81.4257
6 62.50000* 3.48250 .000 51.9077 73.0923
3 1 − 1.00000 3.48250 1.000 − 11.5923 9.5923
2 − 72.83333* 3.48250 .000 − 83.4257 − 62.2410
4 − 66.33333* 3.48250 .000 − 76.9257 − 55.7410
5 − 2.00000 3.48250 .992 − 12.5923 8.5923
6 − 10.33333 3.48250 .059 − 20.9257 .2590
4 1 65.33333* 3.48250 .000 54.7410 75.9257
2 − 6.50000 3.48250 .441 − 17.0923 4.0923
3 66.33333* 3.48250 .000 55.7410 76.9257
5 64.33333* 3.48250 .000 53.7410 74.9257
6 56.00000* 3.48250 .000 45.4077 66.5923
5 1 1.00000 3.48250 1.000 − 9.5923 11.5923
2 − 70.83333* 3.48250 .000 − 81.4257 − 60.2410
3 2.00000 3.48250 .992 − 8.5923 12.5923
4 − 64.33333* 3.48250 .000 − 74.9257 − 53.7410
6 − 8.33333 3.48250 .191 − 18.9257 2.2590
6 1 9.33333 3.48250 .109 − 1.2590 19.9257
2 − 62.50000* 3.48250 .000 − 73.0923 − 51.9077
3 10.33333 3.48250 .059 -.2590 20.9257
4 − 56.00000* 3.48250 .000 − 66.5923 − 45.4077
5 8.33333 3.48250 .191 − 2.2590 18.9257
VAR00001
Tukey HSD



Multiple Comparisons
(I) 1 = 0nm,2 = 20nm,3 = 0nm+NSC23766,4 = 20nm+NSC23766,5 = 0nm+Y-27632,6 = 20nm+Y-27632 (J) 1 = 0nm,2 = 20nm,3 = 0nm+NSC23766,4 = 20nm+NSC23766,5 = 0nm+Y-27632,6 = 20nm+Y-27632 Mean Difference (I-J) Std. Error Sig. 95% Confidence Interval
Lower Bound Upper Bound
Figure 8D
1 2 − 78.00000* 3.68053 .000 − 89.1947 − 66.8053
3 − 4.16667 3.68053 .864 − 15.3613 7.0280
4 − 5.50000 3.68053 .670 − 16.6947 5.6947
5 3.16667 3.68053 .953 − 8.0280 14.3613
6 − 11.00000 3.68053 .056 − 22.1947 .1947
2 1 78.00000* 3.68053 .000 66.8053 89.1947
3 73.83333* 3.68053 .000 62.6387 85.0280
4 72.50000* 3.68053 .000 61.3053 83.6947
5 81.16667* 3.68053 .000 69.9720 92.3613
6 67.00000* 3.68053 .000 55.8053 78.1947
3 1 4.16667 3.68053 .864 − 7.0280 15.3613
2 − 73.83333* 3.68053 .000 − 85.0280 − 62.6387
4 − 1.33333 3.68053 .999 − 12.5280 9.8613
5 7.33333 3.68053 .370 − 3.8613 18.5280
6 − 6.83333 3.68053 .447 − 18.0280 4.3613
4 1 5.50000 3.68053 .670 − 5.6947 16.6947
2 − 72.50000* 3.68053 .000 − 83.6947 − 61.3053
3 1.33333 3.68053 .999 − 9.8613 12.5280
5 8.66667 3.68053 .205 − 2.5280 19.8613
6 − 5.50000 3.68053 .670 − 16.6947 5.6947
5 1 − 3.16667 3.68053 .953 − 14.3613 8.0280
2 − 81.16667* 3.68053 .000 − 92.3613 − 69.9720
3 − 7.33333 3.68053 .370 − 18.5280 3.8613
4 − 8.66667 3.68053 .205 − 19.8613 2.5280
6 − 14.16667* 3.68053 .007 − 25.3613 − 2.9720
6 1 11.00000 3.68053 .056 -.1947 22.1947
2 − 67.00000* 3.68053 .000 − 78.1947 − 55.8053
3 6.83333 3.68053 .447 − 4.3613 18.0280
4 5.50000 3.68053 .670 − 5.6947 16.6947
5 14.16667* 3.68053 .007 2.9720 25.3613
VAR00001
Tukey HSD

The mean difference is significant at the 0.05 level.