Table 1. Photographic and optical coherence tomography characteristics by group and smoking history in patients undergoing macular choroidal thickness evaluationa.
| Group (n=147) | Soft drusen>125 μm | Subretinal drusenoid deposits | Pigmentary abnormality | Mean age (years)b | Mean spherical refraction (diopters)b | Mean macular choroidal thickness (μm) | Mean pack-yearsb |
|---|---|---|---|---|---|---|---|
| Normal (n=49) | 0 | 0 | 0 | 77±6.5 | 0.02±0.23 | 235±49 | — |
| Smoker (n=18) | 14.5±9.6 | ||||||
| Nonsmoker (n=31) | 0 | ||||||
| Drusen (n=38) | 38 | 0 | 0 | 77±6.2 | 0.03±0.41 | 161±39c | — |
| Smoker (n=15) | 15 | 16±13 | |||||
| Nonsmoker (n=23) | 23 | 0 | |||||
| AMD (n=60) | 60 | 42 | 60 | 79±7.1 | 0.05±0.32 | 115±40d | — |
| Smoker (n=34) | 34 | 29 | 34 | 18±16 | |||
| Nonsmoker (n=26) | 26 | 13 | 26 | 0 |
a
CNV, choroidal neovascularization treated no less than 3 months prior in patient's fellow eye; AMD, drusen with additional features of early age-related macular degeneration without geographic atrophy or CNV; P, P-value, statistical significance present for values<0.05; Choroidal thickness measurements obtained via manual caliper tracings at 84 points per eye in central 3 mm of macula, ‘smoker' denotes history of cigarette smoking.
b
No significant difference among diagnosis category means via one-way ANOVA (Age, P=0.163; Spherical refraction, P=0.441; Pack-year history, P=0.093).
c
Significantly less (P<0.001) than normal group (Dunnett's method) and from overall mean (one-way ANOVA).
d
Significantly greater than normal (one-way ANOVA) (P=0.004).