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. 2014 Jun 10;10(2):663–669. doi: 10.3892/mmr.2014.2317

Figure 4.

Figure 4

Human growth factor array and verification of positive hits. (A) Dots on human growth factor antibody arrays. (B) Names of the tested angiogenic factors. Growth factor fold changes of >1.5 in VASH2-overexpressing cells or <0.66 in VASH2 knockdown cells were selected as up- and downregulated, respectively (highlighted). (C) Distinct fold change of four growth factors: FGF2, GDF15, IGFBP3 and IGFBP6. (D) Immunoblot analysis of FGF2 and GDF15. VASH2; vasohibin-2; EGFP, enhanced green fluorescent protein; AR, androgen receptor; BDNF, brain-derived neurotrophic factor; FGF, fibroblast growth factor; BMP, bone morphogenetic protein; EGF, epidermal growth factor; GDF, growth/differentiation factor; HB-EGF, heparin binding-EGF; IGFBP, insulin-like growth factor-binding protein; VEGF, vascular endothelial growth factor.