Figure 4.

Influence of integrin α5 blockade on tumor cell adhesion to HUVEC (A), binding to immobilized collagen or fibronectin (B) and on chemotaxis (C). KTC^par or KTC^res cells were preincubated for 60 minutes with a function-blocking anti–integrin α5 mAb. Controls were untreated. Values are percentage difference to the 100% control. * indicates significant difference between the RCC control subline and the RCC subline treated with the function-blocking antibody. # indicates significant difference between KTC^par and KTC^res cells whose integrin subtype was blocked.