Figure 6.

Integrin β3 blocking studies. KTC^par or KTC^res cells were preincubated for 60 minutes with a function-blocking anti–integrin β3 mAb, and tumor cell adhesion to HUVEC (A), tumor cell binding to immobilized collagen or fibronectin (B), and chemotactic motility (C) were evaluated. Controls remained untreated. Each experiment was repeated five times. Mean values from one representative test are shown as percentage difference to the 100% control. * indicates significant difference between the control RCC and RCC cells treated with the function-blocking antibody. # indicates significant difference between KTC^par and KTC^res cells whose integrin subtype was blocked.