Table W2.
Genes Highly Correlated with Sox2 mRNA Expression in the TCGA Data.
| Gene ID | Correlation | In Vitro Sox2 Knockdown DEG | Sox2 Target (Ref) | Verhaak Subclass |
|---|---|---|---|---|
| ABCA3 | Positive | |||
| ARNT2 | Positive | SDC | ||
| ASTN1 | Positive | CSC | ||
| B3GAT1 | Positive | SDC | (1) | |
| BAALC | Positive | SDC | ||
| BAI2 | Positive | |||
| BCAN | Positive | PN | ||
| C1orf61 | Positive | SDC | (1) | PN |
| C3orf39 | Positive | |||
| CHST10 | Positive | SDC | ||
| CKB | Positive | SDC | PN | |
| CLIP3 | Positive | |||
| CTNND2 | Positive | |||
| DBI | Positive | |||
| DCLK2 | Positive | |||
| DDR1 | Positive | |||
| DENND5A (RAB61P1) | Positive | (1) | ||
| DNAJB5 | Positive | |||
| DTX1 | Positive | |||
| EBF4 | Positive | |||
| FAM181B (MGC33846) | Positive | (1) | ||
| FEZ1 | Positive | SDC | (1) | |
| FXYD6 | Positive | (1) | PN | |
| GDF1 | Positive | |||
| GNA11 | Positive | |||
| GPM6B | Positive | SDC, CSC | ||
| GPR56 | Positive | SDC | CL | |
| HEPN1 | Positive | |||
| ID4 | Positive | |||
| JAKMIP2 | Positive | |||
| KEAP1 | Positive | CL | ||
| LRIG1 | Positive | (1) | ||
| METRN | Positive | SDC | ||
| MLC1 | Positive | CL | ||
| MT3 | Positive | |||
| NFIX | Positive | |||
| NLRP1 | Positive | |||
| NR2F1 | Positive | (1) | ||
| OLIG1 | Positive | |||
| OSBPL6 | Positive | SDC | (1) | |
| PCDHGA1 | Positive | |||
| POU3F2 | Positive | |||
| PTPRZ1 | Positive | (1) | ||
| RGMA | Positive | |||
| SHC3 | Positive | |||
| SLC1A3 | Positive | SDC | (1) | |
| SOX2 | Positive | SDC,CSC | (1) | PN |
| SOX21 | Positive | SDC,CSC | (1) (2) | |
| TBCB | Positive | |||
| TCEA2 | Positive | |||
| TTYH1 | Positive | SDC, CSC | PN | |
| TUBA4A | Positive | |||
| TUBB2A | Positive | |||
| TUBB2B | Positive | SDC | ||
| TUBB6 | Positive | |||
| TUBB8 | Positive | |||
| ZBTB47 | Positive | |||
| ANXA3 | Negative | SDC | NL | |
| ATF1 | Negative | |||
| B3GNT2 | Negative | (1) | ||
| C4orf32 | Negative | (1) | ||
| C6orf211 | Negative | |||
| FEM1B | Negative | |||
| ITGA4 | Negative | MES | ||
| MOB1A | Negative | |||
| MST4 | Negative | |||
| NUDT15 | Negative | |||
| PCYOX1 | Negative | |||
| PTPN2 | Negative | |||
| RALB | Negative | (1) | ||
| STT3B | Negative | |||
| TBC1D8B | Negative | |||
| THOC7 | Negative | |||
| TMF1 | Negative |
References
1. Fang X, Yoon JG, Li L, Yu W, Shao J, Hua D, Zheng S, Hood L, Goodlett DR, Foltz G,et al. (2011). The SOX2 response program in glioblastoma multiforme: an integrated ChIP-seq, expression microarray, and microRNA analysis. BMC Genomics12,11.
2. Ferletta M, Caglayan D, Mokvist L, Jiang Y, Kastemar M, Uhrbom L, Westermark B (2011). Forced expression of Sox21 inhibits Sox2 and induces apoptosis in human glioma cells. Int J Cancer129,45–60.