Table 1.

Ubiquitin pathway modifiers of TNF signaling at 30 min.

Gene ID	Name	Class	Phenotype	Lethal	Nuclear	Potential immune function (NCBI gene report)
NM_001014283	DCUN1D2	Neddylation	Reduced nuclear translocation	N	N	Neddylation of CUL1 (25)
NM_003592	CUL1	SCF E3 component	Reduced nuclear translocation	N	N	Ubiquitylation of I-κB (26)
NM_024907	FBXO17	SCF E3 component	Reduced nuclear translocation	Y	Y	None
NM_033645	FBXW11	SCF E3 component	Reduced nuclear translocation	N	N	Ubiquitylation of I-κB (27)
NM_003482	KMT2D	Lysine methyl transferase	Reduced nuclear translocation	N	N	No clear connection to ubiquitin pathway
NM_001024941	TRIM17	RING motif E3 ligase	Reduced nuclear translocation	N	N	None
NM_017999	RNF31	RING motif E3 ligase	Reduced nuclear translocation	N	N	AKA HOIP (28)
NM_005553	KRTAP5-9	Keratin protein	Reduced nuclear translocation	N	N	No clear connection to ubiquitin pathway
NM_005805	PSMD14	Deubiquitylation	Reduced nuclear translocation	Y	N	Proteasomal component
NM_182488	USP12	Deubiquitylation	Reduced nuclear translocation	N	N	Drosophila IMD response (29)
NM_031907	USP26	Deubiquitylation	Reduced nuclear translocation	N	N	None
NM_020718	USP31	Deubiquitylation	Reduced nuclear translocation	N	N	NF-κB activation (30)