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. 2014 Jul 14;6:145. doi: 10.3389/fnagi.2014.00145

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Copyright © 2014 Aguilar, Muehlboeck, Mecocci, Vellas, Tsolaki, Kloszewska, Soininen, Lovestone, Wahlund, Simmons and Westman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Box-plots illustrating the distribution of (A) Average index according to diagnosis and stratified by pattern of atrophy, all groups are significantly different except for AD-like AD and AD-like MCI-c (--- Two-sided T-test p = 0.76). (B) Index annual rate of change stratified by diagnosis and pattern of atrophy. Index annual rate of change = index at 1-year − index at baseline. ^**Mann-Whitney p = 0.028; Average index = (Index at baseline + index at 1-year)/2. AD, Alzheimer disease; MCI-c, MCI converter; MCI-nc, MCI non-converter (stable); MCI, mild cognitive impairment; CTL, healthy control.