Table 4.

Carotid-sparing IMRT studies in early laryngeal cancer

	Patients (n=)	Tumor stage	Prescription total/single dose (Gy)	Objective	Results
Rosenthal [20]	11	T1-2 N0	65/2.25	Comparison of opposed lateral fields and IMRT	Best carotid-sparing with IMRT
Chera [15]	5	T1N0	63/2.25	Comparison of opposed lateral field, 3D-RT and IMRT	Best carotid-sparing with IMRT
Sert [16]	5	T1N0	62.25/2.25	Comparison of opposed lateral field, 3D-RT and IMRT	Best carotid-sparing with IMRT (V35, V50, V63), identical conformity
Atalar [17]	5	T1N0	63/2.25	Comparison of conformal RT, IMRT and IMAT	More hot spots in IMRT and IMAT, less dose to carotids with IMRT/IMAT
Osman [21]	0 (comparative planning in 10 cases)	T1N0	66/2	Comparison of conventional plans and IMRT (coplanar and non-coplanar)	Contralateral vocal cord sparing best with single vocal cord RT IMRT
Mourad [19]	0 (comparative planning in 1 case)	T1N0	63/2.25	Comparison of 2D, 3D and IMRT plans in a patient with complete left carotid artery occlusion	Minimal dose to right carotid artery and pharyngeal constrictor with IMRT
Riegel [18]	0 (comparative planning in 11 cases)	T1-2 N0	63/2.25	Comparison of lateral opposed fields, VMAT (full-arc, half arc) and IMRT	Full-arc VMAT offers best carotid sparing (and highest mean normal tissue dose), static IMRT produced next-best carotid sparing

IMRT intensity-modulated radiotherapy, IMAT intensity-modulated arc therapy, VMAT volumetric-modulated arc therapy.