Table 1.
Genetic diseases associated with pancreatic cancer risk
| Risk condition | Relative risk | Risk by age 70 | Gene |
| Familial pancreatic cancer | PALLD | ||
| 1 first-degree relative | 2.3-4.5 | 2% | BRCA2 |
| 2 first-degree relatives | 6.4-18 | 3% | PALB2 |
| ≥ 3 first-degree relatives | 32-57 | 16% | |
| Familial atypical multiple mole melanoma | 13-38 | 15%-20% | CDKN2A/p16 |
| Peutz-Jeghers Syndrome | 132 | 11%-60% | STK11/LKB1 |
| Hereditary pancreatitis | 50-87 | 30%-75% | PRSS1 |
| PRSS2 | |||
| SPINK1 | |||
| CTRC | |||
| Cystic fibrosis | 5.3 | <5% | CFTR |
| Familial breast ovarian cancer | 3.5-10 | 5% | BRCA2 |
| 2.3-3.6 | 1% | BRCA1 | |
| Hereditary non-polyposis colon cancer | 2.3-8.6 | 3%-4% | MLH1 |
| MSH2 | |||
| MSH6 | |||
| Familial adenomatous polyposis | 4.5-5 | 2% | FAP |
| MUTYH | |||
| Li Fraumeni sindrome | Unknown | Unknown | TP53 |