Table 1.
Risk condition | Relative risk | Risk by age 70 | Gene |
Familial pancreatic cancer | PALLD | ||
1 first-degree relative | 2.3-4.5 | 2% | BRCA2 |
2 first-degree relatives | 6.4-18 | 3% | PALB2 |
≥ 3 first-degree relatives | 32-57 | 16% | |
Familial atypical multiple mole melanoma | 13-38 | 15%-20% | CDKN2A/p16 |
Peutz-Jeghers Syndrome | 132 | 11%-60% | STK11/LKB1 |
Hereditary pancreatitis | 50-87 | 30%-75% | PRSS1 |
PRSS2 | |||
SPINK1 | |||
CTRC | |||
Cystic fibrosis | 5.3 | <5% | CFTR |
Familial breast ovarian cancer | 3.5-10 | 5% | BRCA2 |
2.3-3.6 | 1% | BRCA1 | |
Hereditary non-polyposis colon cancer | 2.3-8.6 | 3%-4% | MLH1 |
MSH2 | |||
MSH6 | |||
Familial adenomatous polyposis | 4.5-5 | 2% | FAP |
MUTYH | |||
Li Fraumeni sindrome | Unknown | Unknown | TP53 |