Table 1.

Monoclonal plasma cell disorders

Plasma cell disorder	Diagnostic criteria
Monoclonal gammopathy of undetermined significance	Monoclonal serum paraprotein ≤ 3 g/dL and plasma cell infiltration of bone marrow ≤ 10% and no end organ damage1
Asymptomatic smoldering multiple myeloma	Monoclonal serum paraprotein ≥ 3 g/dL and/or plasma cell infiltration of bone marrow ≥ 10% and no end organ damage1
Symptomatic multiple myeloma	Monoclonal paraprotein in serum or urine and/or plasma cell infiltration of bone marrow ≥ 10% and end organ damage1

¹End organ damage: Anemia, hypercalcaemia, renal insufficiency, or bone lesions.