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Common rheumatoid arthritis medications and perioperative considerations
| RA medication | Preoperative action |
| NSAIDs | Discontinue 3-5 half-lives before surgery |
| Corticosteroids | Administer perioperative stress doses |
| Methotrexate | Discontinue for 6-8 wk if possible |
| Biologic agents (TNF-α and interleukin-1 antagonists) | Discontinue preoperatively and hold until 10-14 d post-surgery |
RA: Rheumatoid arthritis; NSAIDs: Non-steroidal anti-inflammatory drugs; TNF-α: Tumor necrosis factor α.
