Table 3.
Mean concentrations (±SD) of FBZ, OXF and FBZSO2 in plasma and in Trichuris suis 12 and 24 h after 1 or 3 times treatment with FBZ (5 mg/kg). Group 1: 12 h after 1 dose of FBZ; groups 2: 24 h after 1 dose of FBZ; group 3: 12 h after 3 doses of FBZ; group 4: 24 h after 3 doses of FBZ.
| n = number of animals | Mean concentration in plasma (pmol/mL) |
n = number of worm samples | Mean concentration in worms (pmol/mg dry worm tissue) |
||||||
|---|---|---|---|---|---|---|---|---|---|
| FBZ | OXF | FBZSO2 | Total | FBZ | OXF | FBZSO2 | Total | ||
| Control (n = 2) | 0 | 0 | 0 | 0 | Control (n = 2) | 0 | 0 | 0 | 0 |
| Group 1 (n = 3) 12 h |
269.31 (±97.20) (7.0) |
2491.16 (±690.77) (64.7) |
1090.15 (±421.54) (28.3) |
3850.62 (100) |
Group 1 (n = 2) |
6.47a,A (±1.1) (14.5) |
20.72b,A (±6.53) (46.3) |
17.53b,A (±3.59) (39.2) |
44.71 (100) |
| Group 2 (n = 3) 24 h |
125.51 (±89.94) (2.8) |
2610.68 (±720.86) (57.9) |
1774.78 (±470.84) (39.3) |
4510.97 (100) |
Group 2 (n = 2) |
14.57a,C (±1.4) (22.7) |
16.02a,C (±10.87) (25.0) |
33.57b,C (± 5.66) (52.3) |
64.16 (100) |
| Group 3 (n = 3) 12 h |
434.64 (±210.43) (4.5) |
5743.10 (±1707.80) (59.5) |
3476.55 (±533.06) (36.0) |
9654.29 (100) |
Group 3 (n = 2) |
29.3a,B (±19.27) (15.8) |
56.73a,B (±1.20) (30.6) |
99.18a,B (±72.48) (53.6) |
185.21 (100) |
| Group 4 (n = 3) 24 h |
237.25 (±53.76) (2.9) |
4030.95 (±342.70) (48.9) |
3974.11 (±1416.90) (48.2) |
8242.31 (100) |
Group 4 (n = 2) |
66.63a,D (±1.6) (39.7) |
26.73b,C (±13.43) (15.9) |
74.67a,C (±75.09) (44.4) |
168.03 (100) |
| Total mean | 235.0 (3.8) |
3432 (55.1) |
2558.1 (41.1) |
6225 (100) |
Total mean | 31.7 (27.7) |
33.0 (28.8) |
49.9 (43.5) |
114.4 (100) |
Each worm sample consisted of triplets except one where only a single subsample was obtained. Significant differences (P < 0.05) within groups (horizontally) are indicated by different superscripts (a and b). Significant differences between groups (vertically) are indicated by different superscripts (A, B for groups 1 and 3 and C, D for groups 2 and 4). Numbers in italic and brackets are relative concentrations (%) in plasma of the pig and T. suis, respectively, measured at each time-point and of the total mean.