Table 4.
Relative (%) and actual concentrations of FBZ, OXF and FBZSO2 in pigs and worms 12 and 24 h after one treatment with FBZ (5 mg/kg).
| 12 h |
Total | 24 h |
Total | |||||
|---|---|---|---|---|---|---|---|---|
| FBZ | OXF | FBZSO2 | FBZ | OXF | FBZSO2 | |||
| Petersen (1998): Plasma (%) (pmol/ml) |
5.0 67 |
75.8 (1268) |
19.2 (362) |
100 (1883) |
8.2 (167) |
54.6 (1111) |
37.1 (754) |
100 (2031) |
| Caecal (%) mucosa (pmol/g) |
58.1 (13028) |
36.8 (8245) |
5.1 (1132) |
100 (22405) |
53.0 (4176) |
20.1 (1586) |
26.8 (2113) |
100 (7874) |
| Caecal (%) content (pmol/g) |
75.7 (8351) |
21.6 (2379) |
2.7 (302) |
100 (11032) |
85.7 (3341) |
8.1 (317) |
6.2 (241) |
100 (3899) |
| Present study (%) | ||||||||
| Plasma | 7 | 64.7 | 28.3 | 100 | 2.8 | 57.9 | 39.3 | 100 |
| Worms (in vivo) | 14.5 | 46.3 | 39.2 | 100 | 22.7 | 25 | 52.3 | 100 |
|
Hansen et al. (2014) Worms (in vitro) |
– | – | – | – | 96 | 4.0 | 0 | 100 |
Relative concentrations in italics are from the present study. Relative concentrations in bold are from the pharmacokinetic study of FBZ in pigs (Petersen, 1998). Concentrations of FBZ, OXF and FBZSO2 in brackets are given in pmol/mL (plasma) and pmol/g (Caecal mucosa and Caecum content). Underlined relative concentrations from a previous in vitro study where Trichuris suis was exposed to 30 μM FBZ (Hansen et al., 2014).