Table 2.
The haplotype frequencies of NR1H3 gene
|
Haplotype |
SLE |
NC |
SLE versus NC |
||
|---|---|---|---|---|---|
| (n = 300) | (n = 217) | P value | OR (95% CI) | ||
| HT1 |
+/+ |
109 (36.3%) |
103 (47.5%) |
co : 0.033 |
0.727 (0.542 ~ 0.974) |
| [TTGG] |
+/- |
169 (56.3%) |
99 (45.6%) |
do : 0.808 |
0.956 (0.681 ~ 1.349) |
| |
-/- |
22 (7.3%) |
15 (6.9%) |
re : 0.012 |
0.796 (0.666 ~ 0.951) |
| HT2 |
+/+ |
16 (5.3%) |
15 (6.9%) |
co : 0.255 |
0.847 (0.636 ~ 1.128) |
| [CTGG] |
+/- |
111 (37.0%) |
87 (40.1%) |
do : 0.280 |
0.908 (0.761 ~ 1.082) |
| |
-/- |
173 (57.7%) |
115 (53.0%) |
re : 0.507 |
0.884 (0.614 ~ 1.273) |
| HT3 |
+/+ |
2 (0.7%) |
0 (0.0%) |
co : 0.008 |
2.739 (1.304 ~ 5.751) |
| [TCGG] |
+/- |
30 (10.0%) |
9 (4.1%) |
do : 0.009 |
1.662 (1.134 ~ 2.435) |
| |
-/- |
268 (89.3%) |
208 (95.9%) |
re : 0.999 |
36085.247 (0.000 ~ NA) |
| HT others |
+/+ |
3 (1.0%) |
0 (0.0%) |
co : <0.001 |
8.375 (2.557 ~ 27.431) |
| |
+/- |
30 (10.0%) |
3 (1.4%) |
do : <0.001 |
2.984 (1.641 ~ 5.427) |
| -/- | 267 (89.0%) | 214 (98.6%) | re : 0.999 | 32475.263 (0.000 ~ NA) | |
Haplotypes (HT) were analyzed using Haploview version 4.1 based on the EM algorithm. Each P value was calculated with co-dominant(co), dominant(do), and recessive(re) models. Logistic regression analysis was applied to control for age and sex as covariables. Two genetic polymorphisms of the NR1H3 gene, -840 C > A and -115 G > A, were in complete linkage disequilibrium. Therefore, -840 C > A was excluded in the haplotype analysis. CI, confidence interval; NA, not applicable; OR, odds ratio.