Table 4.
Reclassification of five-year absolute risk of breast cancer based on a risk model containing Gail variables with and without genetic risk scores (GRS) on 411 breast cancer patients and 1,212 healthy women, The Singapore Chinese Health Study, 1993 to 1998
| Five-year risk without GRS (%) |
Five-year risk with GRS (%) |
|||||
|---|---|---|---|---|---|---|
| <1.0 | 1.0 - <1.5 | 1.5 - <2.0 | 2.0 - <2.5 | ≥2.5 | Total | |
| <1.0 |
|
|
|
|
|
|
| Control |
511 |
84 |
0 |
0 |
0 |
595 |
| Case |
109 |
46 |
0 |
0 |
0 |
155 |
| 1.0 - <1.5 |
|
|
|
|
|
|
| Control |
90 |
356 |
33 |
0 |
0 |
479 |
| Case |
36 |
123 |
39 |
0 |
0 |
198 |
| 1.5 - <2.0 |
|
|
|
|
|
|
| Control |
0 |
53 |
50 |
12 |
0 |
115 |
| Case |
0 |
13 |
19 |
12 |
0 |
44 |
| 2.0 - <2.5 |
|
|
|
|
|
|
| Control |
0 |
0 |
12 |
3 |
1 |
16 |
| Case |
0 |
0 |
4 |
2 |
3 |
9 |
| >2.5 |
|
|
|
|
|
|
| Control |
0 |
0 |
0 |
2 |
5 |
7 |
| Case |
0 |
0 |
0 |
1 |
4 |
5 |
| Total |
|
|
|
|
|
|
| Control |
601 |
493 |
94 |
18 |
6 |
1,212 |
| Case | 145 | 182 | 62 | 15 | 7 | 411 |