Figure 4.
Histone H3-induced lung injury. Histological changes in mouse lung 3 hours after 50 mg/kg intravenous histone H3. Macroscopic findings of the lung demonstrate massive bleeding and edema compared to the control (lower left corner). Remarkable bleeding was recognized in the surrounding part of the trachea and the vessels microscopically. (Hematoxylin-eosin staining; ×20 objective lens).