Table 2.
Comparisons of the risk allele frequencies of 19 systemic lupus erythematosus autosomal loci in patients and controls stratified by sex and between men and women with SLE a
| |
|
Men
b
|
Women
b
|
SLE men/SLE women |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP c | Gene locus | SLE | Control | OR (95% CI) | P-value | SLE | Control | OR (95% CI) | P-value | OR (95% CI) d | P-value |
| rs2476601 |
PTPN22 |
0.114 |
0.070 |
1.70 (1.09 to 2.64) |
0.017 |
0.097 |
0.076 |
1.31 (1.08 to 1.60) |
7.2 × 10−3 |
1.19 (0.80 to 1.77) |
0.4 |
| rs1801274 |
FCGR2A |
0.493 |
0.474 |
1.08 (0.82 to 1.41) |
0.6 |
0.511 |
0.474 |
1.15 (1.03 to 1.29) |
0.011 |
0.93 (0.72 to 1.20) |
0.6 |
| rs2205960 |
TNFSF4 |
0.257 |
0.209 |
1.31 (0.96 to 1.79) |
0.09 |
0.264 |
0.220 |
1.27 (1.12 to 1.45) |
3.1 × 10−4 |
0.97 (0.72 to 1.29) |
0.8 |
| rs7574865 |
STAT4 |
0.306 |
0.209 |
1.67 (1.24 to 2.25) |
7.1 × 10−4 |
0.325 |
0.243 |
1.49 (1.32 to 1.69) |
2.8 × 10−10 |
0.92 (0.70 to 1.20) |
0.5 |
| rs6445975 |
PXK |
0.311 |
0.241 |
1.42 (1.06 to 1.91) |
0.018 |
0.264 |
0.226 |
1.23 (1.08 to 1.40) |
2.2 × 10−3 |
1.26 (0.96 to 1.66) |
0.09 |
| rs17266594 |
BANK1e |
0.730 |
0.715 |
1.07 (0.80 to 1.45) |
0.6 |
0.751 |
0.708 |
1.24 (1.09 to 1.41) |
7.5 × 10−4 |
0.89 (0.67 to 1.19) |
0.4 |
| rs3131379 |
MSH5 (HLA) |
0.132 |
0.071 |
1.98 (1.30 to 3.02) |
1.2 × 10−3 |
0.146 |
0.072 |
2.20 (1.82 to 2.66) |
9.6 × 10−17 |
0.89 (0.62 to 1.29) |
0.5 |
| rs729302 |
IRF5 |
0.711 |
0.689 |
1.11 (0.83 to 1.49) |
0.5 |
0.748 |
0.691 |
1.33 (1.17 to 1.50) |
1.0 × 10−5 |
0.83 (0.63 to 1.10) |
0.2 |
| rs10488631 |
IRF5e |
0.184 |
0.111 |
1.81 (1.26 to 2.61) |
1.2 × 10−3 |
0.183 |
0.097 |
2.09 (1.76 to 2.48) |
1.0 × 10−17 |
1.01 (0.73 to 1.40) |
0.96 |
| rs10954213 |
IRF5 |
0.639 |
0.638 |
1.01 (0.76 to 1.33) |
0.97 |
0.685 |
0.643 |
1.21 (1.07 to 1.36) |
1.9 × 10−3 |
0.82 (0.63 to 1.06) |
0.13 |
| rs13277113 |
C8orf13-BLK |
0.274 |
0.250 |
1.13 (0.84 to 1.53) |
0.4 |
0.311 |
0.245 |
1.39 (1.23 to 1.58) |
2.8 × 10−7 |
0.84 (0.63 to 1.11) |
0.2 |
| rs4963128 |
KIAA1542 |
0.715 |
0.645 |
1.38 (1.03 to 1.85) |
0.03 |
0.696 |
0.662 |
1.17 (1.04 to 1.32) |
0.010 |
1.10 (0.83 to 1.45) |
0.5 |
| rs1143679 |
ITGAM |
0.299 |
0.169 |
2.10 (1.54 to 2.85) |
1.6 × 10−6 |
0.230 |
0.153 |
1.65 (1.42 to 1.90) |
1.2 × 10−11 |
1.43 (1.08 to 1.88) |
0.011 |
| rs2304256 |
TYK2 |
0.735 |
0.723 |
1.06 (0.79 to 1.44) |
0.7 |
0.770 |
0.727 |
1.26 (1.11 to 1.43) |
4.8 × 10−4 |
0.83 (0.62 to 1.11) |
0.2 |
| rs5754217 |
UBE2L3 |
0.244 |
0.209 |
1.22 (0.89 to 1.67) |
0.2 |
0.254 |
0.218 |
1.22 (1.07 to 1.39) |
2.8 × 10−3 |
0.95 (0.71 to 1.27) |
0.7 |
| rs2230926 |
TNFAIP3 |
0.070 |
0.039 |
1.87 (1.07 to 3.27) |
0.026 |
0.074 |
0.041 |
1.87 (1.45 to 2.40) |
7.0 × 10−7 |
0.95 (0.58 to 1.55) |
0.8 |
| rs573775 |
ATG5 |
0.256 |
0.263 |
0.96 (0.71 to 1.30) |
0.8 |
0.301 |
0.269 |
1.17 (1.04 to 1.33) |
0.012 |
0.80 (0.60 to 1.06) |
0.12 |
| rs2187668 |
HLA-DQA1 |
0.184 |
0.107 |
1.87 (1.30 to 2.69) |
6.0 × 10−4 |
0.201 |
0.105 |
2.15 (1.82 to 2.52) |
7.4 × 10−21 |
0.89 (0.65 to 1.23) |
0.5 |
| rs10798269 | 1q25.1 | 0.733 | 0.656 | 1.20 (0.89 to 1.62) | 0.2 | 0.729 | 0.680 | 1.26 (1.12 to 1.43) | 1.7 × 10−4 | 1.02 (0.77 to 1.36) | 0.9 |
aSLE, Systemic lupus erythematosus; SNP, Single-nucleotide polymorphism. bSLE men = 136; control men = 540; SLE women = 1,321; Control women = 1,188. cThe 13 first loci are the same as those studied by Hughes et al. [9]. dOR > 1.0 indicates higher frequency of the risk allele in men than in women. er2 = 0.94 with rs10516487 used for BANK1 and r2 = 0.94 for rs2070197 used for IRF5[9].