Table 3.
Levels of 33 cytokines showing no significant difference between mild or moderately severe and severe acute pancreatitis a
| Cytokines | Mild or moderately severe AP ( n = 138) | P- value b | Severe AP ( n = 25) |
|---|---|---|---|
| CTACK |
993.1 (746.4 to 1,556.1) |
0.033 (NS) |
693.3 (652.5 to 1,150.6) |
| Eotaxinc |
1 (0 to 1) |
0.133 (NS) |
1 (0 to 1) |
| FGF |
25.9 (8.6 to 44.6) |
0.123 (NS) |
19.4 (0.4 to 35.2) |
| GM-CSFc |
0 (0) |
0.663 (NS) |
0 (0 to 1) |
| IFN-γ |
99.5 (50.7 to 151.0) |
0.772 (NS) |
82.4 (50.9 to 149.5) |
| IP-10 |
379.3 (244.5 to 594.0) |
0.475 (NS) |
446.2 (222.6 to 825.3) |
| IL-1αc |
0 (0 to 1) |
0.473 (NS) |
1 (0 to 1) |
| IL-1β |
1.9 (0.8 to 3.0) |
0.961 (NS) |
1.9 (0.5 to 3.4) |
| IL-1Ra |
121.1 (64.8 to 260.0) |
0.131 (NS) |
202.6 (70.9 to 669.8) |
| IL-2 |
7.6 (2.2 to 13.4) |
0.796 (NS) |
6 to 7 (1.7 to 12.9) |
| IL-3c |
0 (0) |
0.008 (NS) |
0 (0 to 1) |
| IL-4 |
5.1 (2.6 to 7.5) |
0.261 (NS) |
3.8 (2.3 to 6.4) |
| IL-5 |
2.7 (1.6 to 4.1) |
0.091 (NS) |
1.8 (1.0 to 3.4) |
| IL-7 |
5.9 (3.9 to 10.5) |
0.482 (NS) |
5.2 (3.9 to 9.4) |
| IL-9 |
19.5 (7.3 to 37.8) |
0.410 (NS) |
16.1 (1.7 to 38.7) |
| IL-10 |
8.2 (3.9 to 17.7) |
0.012 (NS) |
15.8 (6.2 to 42.3) |
| IL-12p70 |
18.7 (11.2 to 40.4) |
0.442 (NS) |
15.5 (9.0 to 36.5) |
| IL-12p40c |
0 (0) |
0.691 (NS) |
0 (0) |
| IL-13 |
7.2 (3.9 to 13.5) |
0.249 (NS) |
6.5 (2.6 to 12.1) |
| IL-15c |
0 (0) |
0.018 (NS) |
0 (0 to 1) |
| IL-16 |
220.2 (99.9 to 786.8) |
0.120 (NS) |
341.3 (157.2 to 980.1) |
| IL-17A |
79.8 (33.2 to 155.9) |
0.084 (NS) |
45.8 (9.2 to 98.4) |
| MIP-1α |
6.2 (3.7 to 8.0) |
0.215 (NS) |
4.6 (2.4 to 7.1) |
| MIP-1β |
67.1 (42.6 to 90.2) |
0.830 (NS) |
63.6 (40.1 to 95.8) |
| MIF |
695.8 (348.5 to 1,553.9) |
0.004 (NS) |
1461.2 (713.4 to 4,529.4) |
| MIG |
1,415.5 (821.0 to 2,348.2) |
0.021 (NS) |
2,147.5 (1,257.4 to 4,268.7) |
| PDGF-BB |
1,183.6 (360.4 to 2,475.2) |
0.063 (NS) |
583.3 (207.8 to 1,427.3) |
| RANTES |
2,905.6 (1,110.3 to 4,511.1) |
0.093 (NS) |
1,877.2 (787.5 to 3,090.9) |
| SCGF-β |
31452.4 (21610.3 to 46978.0) |
0.004 (NS) |
47129.9 (30743.1 to 56343.2) |
| TRAIL |
57.4 (33.3 to 92.0) |
0.042 (NS) |
84.8 (51.8 to 122.7) |
| TNF-α |
20.8 (10.3 to 31.9) |
0.730 (NS) |
18.2 (9.7 to 31.5) |
| TNF-βc |
0 (0 to 1) |
0.187 (NS) |
0 (0) |
| VEGF | 29.9 (17.7 to 71.1) | 0.436 (NS) | 23.6 (17.4 to 64.2) |
aAP, Acute pancreatitis; CTACK, Cutaneous T-cell attracting chemokine; FGF, Basic fibroblast growth factor; GM-CSF, Granulocyte-macrophage colony-stimulating factor; IFN, Interferon; IL, Interleukin; IL-1Ra, Interleukin 1 receptor antagonist; IP-10, Interferon-γ-induced protein 10; VEGF, vascular endothelial growth factor; MIF, Macrophage migration inhibitory factor; MIG, Monokine induced by interferon γ; MIP, Macrophage inflammatory protein; VEGF, vascular endothelial growth factor; PDGF-BB, Platelet-derived growth factor, two BB chains; RANTES, Regulated on activation, normal T cell expressed and secreted; SCGF-β, Stem cell growth factor β; TNF, Tumor necrosis factor; TRAIL, Tumor necrosis factor–related apoptosis-inducing ligand; VEGF, Vascular endothelial growth factor IQR, interquartile range; NS, Not significant. bLevel of significance is defined as P < 0.001 (Bonferroni-adjusted). c0 = Undetectable value, 1 = Detectable value. Data are median (IQR).