Table 7.
Diagnostic performances of biomarkers markers in predicting severe acute pancreatitis in patients with admission modified Marshall score <2 ( N = 142) a
| Predictive marker and optimal cutoff point | AUC | Sensitivity (%) | Specificity (%) | LR+ | LR- | DOR |
|---|---|---|---|---|---|---|
| IL-8 (>88.1 pg/ml) |
0.79 (0.68 to 0.90) |
25.6 (11.7 to 54.7) |
95.3 (90.2 to 97.8) |
6.1 (2.0 to 19.0) |
0.75 (0.54 to 1.05) |
8.1 (2.0 to 33.6) |
| HGF (>3,020.1 pg/ml) |
0.83 (0.73 to 0.92) |
28.6 (11.7 to 54.7) |
95.3 (0.90 to 97.8) |
6.1 (2.0 to 19.0) |
0.75 (0.54 to 1.05) |
8.1 (2.0 to 33.6) |
| G-CSF (>477.7 pg/ml) |
0.78 (0.65 to 0.90) |
35.6 (16.3 to 61.2) |
96.1 (91.2 to 98.3) |
9.1 (3.0 to 27.7) |
0.67 (0.45 to 0.99) |
13.7 (3.3 to 56.1) |
| CRP (>227 mg/L) |
0.54 (0.37 to 0.70) |
7.1 (1.3 to 31.5) |
95.3 (90.2 to 97.8) |
1.5 (0.2 to 11.8) |
0.97 (0.2 to 11.8) |
1.6 (0.2 to 14.0) |
| Creatinine (>141 μmol/L) |
0.62 (0.45 to 0.79) |
7.1 (1.3 to 31.5) |
99.2 (95.7 to 99.9) |
9.1 (0.6 to 37.2) |
0.94 (0.91 to 1.08) |
9.7 (0.57 to 164.2) |
| Calcium (<1.91 mmol/L) |
0.74 (0.60 to 0.88) |
36.4 (15.2 to 64.6) |
94.3 (88.7 to 97.2) |
6.4 (2.2 to 18.5) |
0.68 (0.43 to 1.06) |
9.5 (2.2 to 40.2) |
| G-CSF + IL-8 + HGF | 57.1 (32.6 to 78.6) | 90.6 (84.3 to 94.6) | 6.1 (3.0 to 12.3) | 0.47 (0.26 to 0.87) | 12.9 (3.8 to 43.4) |
aIL, Interleukin; CRP, C-reactive protein; IL, interleukin; G-CSF, Granulocyte colony-stimulating factor; HGF, Hepatocyte growth factor; IL, Interleukin; AUC, Area under the curve; DOR, Diagnostic odds ratio; LR-, Negative likelihood ratio; LR+, Positive likelihood ratio. 95% confidence intervals are given in parentheses.