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| Stage 1 | Stage 2 | Stage 3 | Stage 4 | P-value | |
|---|---|---|---|---|---|
| sIL-2R (pg/mL ± SD) | 687.9 ± 497.4 | 725.1 ± 740.6 | 725.3 ± 460.9 | 2021.9 ± 1922.4 | P < 0.001 |
| sB7-H3 (ng/mL ± SD) | 14.7 ± 12.4 | 10.2 ± 2.5 | 12.2 ± 6.9 | 17.4 ± 9.3 | P = 0.044 |
| sCTLA-4 (ng/mL ± SD) | 2.2 ± 0.7 | 1.9 ± 0.3 | 2.5 ± 1.1 | 2.3 ± 0.6 | P = 0.179 |
CCRCC: clear cell renal cell carcinoma, sIL-2R: soluble interleukin-2 receptor, sB7-H3: soluble B7-H3, and sCTLA-4: soluble cytotoxic T lymphocyte associated antigen-4.
