Table 2.
Bacteria shown to be protective in inflammatory bowel disease
| Bacterial Strain/s | Model system | IBD type/ model | Mechanism of suppression |
|---|---|---|---|
| VSL#3 | Human/ mouse | Pouchitis, Ulcerative colitis/ TNBS | IL-10, TGF-β bearing T cells |
| Bifidobacteria lactis | Rat | TNBS | ↓ colonic TNF-α and iNOS |
| Bifidobacteria infantis | Mouse | S. typhimurium induced enteritidis | Tregs, inhibits NF-κB |
| E. coli Nissle 1917 | Human/ mouse | Ulcerative colitis/ DSS colitis | ↓ inflammation via TLR-2 & TLR-4 |
| Lactobacillus rhamnosus GG | Mouse/ Rat | TNBS/HLA-B27 | induction of CD4+CD25+ cells |
| Lactobacillus salivarius | Mouse | TNBS | ↓ colonic inflammation |
| Lactobacillus reuteri | Mouse | IL-10−/− mice | NGF and ↓ IL-8, TNF in cell lines |
| Lactobacillus plantarum 299v | Mouse | IL10 −/− mice, but not TNBS | ↓ IFN-γ and IL-12p40 |
| Lactobacillus fermentum | Rat | TNBS | ↓ colonic TNF-α and iNOS |
| Lactobacillus casei | Rat | TNBS | ↓ colonic COX-2 |
| Bacteriodes thetaiotaomicron | Rat | S.enterica induced enteritidis | ↓ IL-8 and TNF-α in Caco-2 cells |
| Bacteriodes fragilis | Mouse | T cell transfer model, TNBS | CD4+ T cell derived IL-10 |
| YO-MIX Y109 FRO 1000 | Mouse | TNBS | ND |
| Faecalibacterium prausnitzii | Mouse | TNBS | ↓ NF-κB and IL-8 |