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. Author manuscript; available in PMC: 2014 Jul 14.
Published in final edited form as: Arthritis Rheum. 2013 Jan;65(1):159–166. doi: 10.1002/art.37750

Figure 2.

Figure 2

Lower glycosaminoglycan (GAG), aggrecan, and type II collagen content in articular cartilage from SIRT-1y/y (y/y) mice than their wild-type (WT) littermates. A, Alcian blue staining (for GAG content), aggrecan staining, and type II collagen staining of paw sections from 5-month-old WT and y/y mice. Alcian blue, aggrecan, and type II collagen staining intensity were reduced by 65%, 50%, and 19%, respectively, in the paws of y/y mice compared to those of WT mice. Arrows indicate the difference in staining intensity for each marker. Original magnification × 10. B, Alcian blue staining (for GAG content), aggrecan staining, and type II collagen staining of knee sections from 5-month-old WT and y/y mice. Staining intensity was reduced in the knees of the y/y mice, similar to the findings in paws. Arrows indicate the difference in staining intensity for each marker. Original magnification × 16.